Modulation of Dendritic Cells by Endurance Training
| العنوان: | Modulation of Dendritic Cells by Endurance Training |
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| المؤلفون: | Hui-Fen Liao, Y.-J. Chen, Jasson Chiang, L.-M. Chiang, L.-Y. Lai, Y.-Y. Chen |
| المصدر: | International Journal of Sports Medicine. 28:798-803 |
| بيانات النشر: | Georg Thieme Verlag KG, 2007. |
| سنة النشر: | 2007 |
| مصطلحات موضوعية: | medicine.medical_specialty, Time Factors, Genes, MHC Class II, Antigen-Presenting Cells, Physical Therapy, Sports Therapy and Rehabilitation, Kidney, Rats, Sprague-Dawley, Immune system, Bone Marrow, Endurance training, Internal medicine, medicine, Animals, Orthopedics and Sports Medicine, Antigen-presenting cell, Interleukin 4, MHC class II, biology, business.industry, Body Weight, Granulocyte-Macrophage Colony-Stimulating Factor, Interleukin, Dendritic Cells, Interleukin-12, Rats, Endocrinology, Granulocyte macrophage colony-stimulating factor, Liver, Immunology, Physical Endurance, biology.protein, Interleukin 12, Interleukin-4, Lymphocyte Culture Test, Mixed, business, medicine.drug |
| الوصف: | A periodized endurance training is able to adapt physical and psychological needs and increase exercise performance. Dendritic cells (DCs) play a key role in regulation of the immune response. In the present study, we trained Sprague-Dawley (SD) rats for five weeks using a progressive endurance protocol with the aim of measuring the effect on myeloid DC differentiation and maturation. Rats were divided into a non-exercise group (NEG) and an exercise group (EG). Bone marrow cells were isolated from these rats after training and cultured in the presence of granulocyte/monocyte-colony stimulatory factor (GM-CSF) and interleukin (IL)-4, and the resultant immature DCs were triggered with lipopolysaccharide to mature. DCs were collected and the main characteristics of DCs were assessed. The recovery rate and the expression of major histocompatibility complex (MHC) class II molecules for DC collected from EG was markedly greater than NEG. The function of DCs from EG to trigger a mixed leukocyte reaction and IL-12 production was higher than NEG. There was no liver and renal toxicity observed in all rats. Changes in food/water consumption and body weight increase between the groups were normal for the conditions. This study demonstrated that periodized endurance training is able to modulate DC development and shift them towards a more mature state. |
| تدمد: | 1439-3964 0172-4622 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::00108a8b82bf3b979e52551f1fd40756Test https://doi.org/10.1055/s-2007-964914Test |
| رقم الانضمام: | edsair.doi.dedup.....00108a8b82bf3b979e52551f1fd40756 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14393964 01724622 |
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