Elevation of Amniotic Fluid Interleukin-4 Concentrations in Women with Preterm Labor and Chorioamnionitis
| العنوان: | Elevation of Amniotic Fluid Interleukin-4 Concentrations in Women with Preterm Labor and Chorioamnionitis |
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| المؤلفون: | Murray D. Mitchell, Donald J. Dudley, Michael W. Varner, Cheri Hunter |
| المصدر: | ResearcherID |
| بيانات النشر: | Georg Thieme Verlag KG, 1996. |
| سنة النشر: | 1996 |
| مصطلحات موضوعية: | Adult, medicine.medical_specialty, Amniotic fluid, Preterm labor, medicine.medical_treatment, Chorioamnionitis, Proinflammatory cytokine, Pathogenesis, Obstetric Labor, Premature, Pregnancy, medicine, Humans, Interleukin 4, Obstetrics, business.industry, Obstetrics and Gynecology, Increased amniotic fluid, Amniotic Fluid, medicine.disease, Cytokine, Case-Control Studies, Pediatrics, Perinatology and Child Health, Interleukin-2, Female, Interleukin-4, business |
| الوصف: | Preterm labor associated with intrauterine infection is characterized by increased amniotic fluid concentrations of various proinflammatory cytokines, including interleukin-1beta (IL-1beta), tumor necrosis factor-alpha (TNF-alpha), IL-6, IL-8, and macrophage inflammatory protein-1alpha (MIP-1alpha). The purpose of this study was to determine if preterm labor in women with clinically evident chorioamnionitis is marked by elevations of the anti-inflammatory cytokine interleukin-4 (IL-4) and the T cell growth factor IL-2. Amniotic fluid samples were obtained from (1) women at term, not in labor (n = 10); (2) women at term, in labor (n = 10); (3) women with preterm contractions but undelivered within 1 week of amniotic fluid collection (n = 10); (4) women with preterm labor and delivery without clinically evident chorioamnionitis (n = 10); (5) women with preterm labor associated with chorioamnionitis (n = 8); and (6) women with preterm labor and delivery without infection matched with patients with chorioamnionitis (n = 8). Amniotic fluid concentrations of IL-4 and IL-2 were determined for each sample with a specific and sensitive enzyme-linked immunoassay. We found that women with infection-associated preterm labor and delivery had significantly higher concentrations of IL-4 when compared to appropriately matched controls (p0.05). Additionally, women with preterm labor and delivery not associated with infection had higher amniotic fluid IL-4 concentrations than women with preterm contractions but no labor (p0.05). Women with term labor had rare modest elevations of amniotic fluid IL-4. No IL-2 was detected in any sample. Our data indicate that amniotic fluid IL-4 is elevated in women with preterm labor and delivery, particularly in association with chorioamnionitis. We suggest that IL-4, although previously considered an anti-inflammatory agent, may have a paradoxical proinflammatory role in the pathogenesis of infection-associated preterm labor. |
| تدمد: | 1098-8785 0735-1631 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d41ec9cfa86dcc3743076d271c5cdd5Test https://doi.org/10.1055/s-2007-994385Test |
| رقم الانضمام: | edsair.doi.dedup.....0d41ec9cfa86dcc3743076d271c5cdd5 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 10988785 07351631 |
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