Prevention of Brain Metastasis Formation by Local Expression of Interleukin-4 or Hemagglutinin Antigen
| العنوان: | Prevention of Brain Metastasis Formation by Local Expression of Interleukin-4 or Hemagglutinin Antigen |
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| المؤلفون: | Hans K. Schackert, Eberhard Kuhlisch, A. Steinmetz, Weilemann F, Gabriele Schackert, Matthias Kirsch, A. Buttler, S. Kunze |
| المصدر: | Zentralblatt für Neurochirurgie. 64:65-70 |
| بيانات النشر: | Georg Thieme Verlag KG, 2003. |
| سنة النشر: | 2003 |
| مصطلحات موضوعية: | Hemagglutinin (influenza), Hemagglutinin Glycoproteins, Influenza Virus, Virus, Mice, Cecum, Antigen, Tumor Cells, Cultured, medicine, Animals, Interleukin 4, Mice, Inbred BALB C, Lung, biology, Brain Neoplasms, business.industry, medicine.disease, Survival Analysis, medicine.anatomical_structure, Injections, Intra-Arterial, Immunization, Colonic Neoplasms, Immunology, Cancer research, biology.protein, Female, Surgery, Interleukin-4, Neurology (clinical), business, Carotid Artery, Internal, Neoplasm Transplantation, Brain metastasis |
| الوصف: | INTRODUCTION Expression of hemagglutinin antigen of influenza virus (HA) by the murine colon carcinoma cell line (CT-26) produces systemic immunization against tumor challenges in the cecum, liver and lungs but not in the brain of BALB/c-mice. Immunization with IL-4 expressing CT-26 cells inhibits lung metastases formation. The purpose of our study was to examine the effects of HA or IL-4 expression on brain metastases formation. METHODS Using selective internal carotid artery injections, brain metastases formation of HA or IL-4 expressing CT-26 cells with and without subcutaneous pre-immunization was evaluated in Balb/c mice. RESULTS Systemic pre-immunization with HA or IL-4 expressing tumor cells cannot protect against brain metastases, while the local, intracerebral expression of HA or IL-4 inhibits the growth of hematogenous brain metastases. CONCLUSION Pre-immunization with HA or IL-4 expressing tumor cells did produce systemic immunity against liver and lung metastases but not against brain metastases. Local, intracerebral expression of HA or IL-4 prevents from cerebral metastases formation in an animal model. |
| تدمد: | 1438-9746 0044-4251 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e54b3efa6b907e248b84672245416e77Test https://doi.org/10.1055/s-2003-40374Test |
| رقم الانضمام: | edsair.doi.dedup.....e54b3efa6b907e248b84672245416e77 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14389746 00444251 |
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