Neolignans from the Fruits of Magnolia obovata and Their Inhibition Effect on NO Production in LPS-Induced RAW 264.7 Cells
| العنوان: | Neolignans from the Fruits of Magnolia obovata and Their Inhibition Effect on NO Production in LPS-Induced RAW 264.7 Cells |
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| المؤلفون: | Ji-Hae Park, In-Sik Chung, Geum-Soog Kim, Dae Young Lee, Sabina Shrestha, Dong-Sung Lee, Rak-Hun Jeong, Youn-Chul Kim, Kyeong-Hwa Seo, Ye-Jin Jung, Nam-In Baek |
| المصدر: | Planta Medica. 79:1335-1340 |
| بيانات النشر: | Georg Thieme Verlag KG, 2013. |
| سنة النشر: | 2013 |
| مصطلحات موضوعية: | Lipopolysaccharides, Honokiol, Stereochemistry, Anti-Inflammatory Agents, Pharmaceutical Science, DEPT, Nitric Oxide, Lignans, Cell Line, Analytical Chemistry, Mice, chemistry.chemical_compound, Column chromatography, Drug Discovery, Animals, RAW 264.7 Cells, Inflammation, Pharmacology, Chromatography, Molecular Structure, biology, Plant Extracts, Macrophages, Organic Chemistry, biology.organism_classification, Magnolol, Magnoliaceae, Complementary and alternative medicine, chemistry, Magnolia, Fruit, Molecular Medicine, Obovatol, Magnolia obovata |
| الوصف: | Three new neolignans, named 9-methoxyobovatol (6), magnobovatol (7), and 2-hydroxyobovaaldehyde (9), along with six known ones, magnolol (1), honokiol (2), isomagnolol (3), obovatol (4), obovatal (5), and obovaaldehyde (8), were isolated from the fruits of Magnolia obovata using silica gel and ODS column chromatography. From the results of spectroscopic data including EIMS, IR, 1H- and 13C-NMR, DEPT, and 2D-NMR (gCOSY, gHSQC, gHMBC), the chemical structures were determined. All isolated compounds were evaluated for inhibition activity on nitric oxide production in LPS-induced RAW 264.7 cells, and compounds 1-4, 6, 7, and 9 showed significant activity with IC50 values of 15.8 ± 0.3, 3.3 ± 1.2, 14.1 ± 0.9, 6.2 ± 1.2, 14.8 ± 2.3, 14.2 ± 1.2, and 14.8 ± 3.2 µM, respectively, without any visible toxic effect. |
| تدمد: | 1439-0221 0032-0943 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f22261a5ecd8d92653b0c5ea4a45124eTest https://doi.org/10.1055/s-0033-1350673Test |
| رقم الانضمام: | edsair.doi.dedup.....f22261a5ecd8d92653b0c5ea4a45124e |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14390221 00320943 |
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