A GLP-1 Receptor Agonist Inhibits Aldosterone Release in Healthy Volunteers
| العنوان: | A GLP-1 Receptor Agonist Inhibits Aldosterone Release in Healthy Volunteers |
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| المؤلفون: | Vallo Volke, Keiu Heinla, Eero Vasar, Tuuli Sedman |
| المصدر: | Hormone and Metabolic Research. 53:402-407 |
| بيانات النشر: | Georg Thieme Verlag KG, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Adult, Male, Hypothalamo-Hypophyseal System, medicine.medical_specialty, Adolescent, Hydrocortisone, Endocrinology, Diabetes and Metabolism, Clinical Biochemistry, Pituitary-Adrenal System, 030209 endocrinology & metabolism, Stimulation, Biochemistry, Glucagon-Like Peptide-1 Receptor, Young Adult, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Endocrinology, Therapeutic index, Internal medicine, Renin–angiotensin system, Humans, Medicine, Receptor, Aldosterone, Glucagon-like peptide 1 receptor, business.industry, Biochemistry (medical), General Medicine, Middle Aged, Healthy Volunteers, chemistry, Ambulatory, Exenatide, Female, business, 030217 neurology & neurosurgery, Follow-Up Studies, medicine.drug |
| الوصف: | Glucagon-like peptide 1 receptor agonists (GLP-1 RAs) are antidiabetic drugs with effects beyond antihyperglycemic action. The aim of the study was to examine whether a single dose of exenatide could be used as a stimulation test for the pituitary-adrenal axis. We carried out a single-group, open-label pilot clinical trial in an ambulatory setting. Ten healthy volunteers of both sexes with body weight>65 kg and age between 18–50 years were recruited. After fasting for 12 hours the subjects received 10 μg of exenatide solution subcutaneously. Blood samples were taken before the administration of exenatide and up to 150 minutes thereafter. The primary outcome was the maximal level of cortisol after the administration of exenatide. Single administration of exenatide 10 μg resulted in a modest increase in ACTH and cortisol levels, as compared to untreated values, and a decrease in blood glucose levels. Remarkably, a robust suppression of both renin and aldosterone levels occurred. We showed that acute administration of exenatide in a full therapeutic dose modestly stimulates the hypothalamic-pituitary-adrenal axis but inhibits the renin-aldosterone system. Further research is warranted to confirm this finding in the placebo-controlled study. |
| تدمد: | 1439-4286 0018-5043 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::149b814c82d922838be804b633c5d5f0Test https://doi.org/10.1055/a-1498-7098Test |
| رقم الانضمام: | edsair.doi.dedup.....149b814c82d922838be804b633c5d5f0 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14394286 00185043 |
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