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Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits

التفاصيل البيبلوغرافية
العنوان: Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits
المؤلفون: Harris TB, Tuomilehto J, Harder MN, James AL, Silbernagel G, Hutri-Kahonen N, Rudan I, Navarro P, Mahajan A, Kolcic I, Kutalik Z, Jackson AU, Balkau B, Marten J, Rankinen T, Stott DJ, Bandinelli S, Liu CT, Schlessinger D, Bien SA, Vestergaard H, Direk N, Holmen OL, van der Laan SW, Alfred T, Scholtens S, Marques-Vidal P, Olden M, Fisher VA, Hocking LJ, Kleber ME, Frayling TM, Eicher JD, Launer LJ, Lim U, Xue L, Lee NR, Lehtimaki T, Metspalu A, Rao DC, Jarvelin MR, Pervjakova N, Rasmussen-Torvik LJ, Chittani M, Strauch K, Lindgren CM, Qi L, Bergmann S, Volzke H, Heid IM, Strachan DP, Hottenga JJ, Hansen T, Haitjema S, Sorensen TIA, Kuh D, Bergman RN, Pasterkamp G, Sennblad B, McCarthy MI, Gong J, Nauck M, Bartz TM, Waeber G, Chasman DI, Strawbridge RJ, Dedoussis G, Justice AE, Wild S, Faul JD, Taylor KD, Chu AY, Hollensted M, Vedantam SL, Raitakari OT, Rauramaa R, Loh M, Eriksson J, Justesen JM, Savonen K, Cupples LA, Borecki IB, Fox CS, Hastie ND, Kivimaki M, Gudnason V, Heath AC, Narisu N, Madden PAF, Mohlke KL, Pisinger C, Wu Y, Eiriksdottir G, Barroso I, Perez J, Musk AW, Heard-Costa NL, Ludolph-Donislawski A, Lind L, Bonnycastle LL, Tyrrell J, Bragg J, Zhao W, Kvaloy K, Hassinen M, Lim E, Rice T, Hadley D, Froguel P, Winkler TW, Padmanabhan S, Gorski M, Chambers JC, Weir DR, Grabe HJ, Hirschhorn JN, Barata L, Curran JE, Campbell H, Peters U, Boehnke M, Peters A, Deng X, Langenberg C, Wilson JF, Loos RJF, de Borst GJ, Zubair N, Marchini J, Tayo BO, Afzal U, Hamsten A, Deloukas P, Hindorff L, Esko T, Chen YDI, Cusi D, Baldassarre D, Palmer LJ, Mellstrom D, Hayward C, de Faire U, Wright AF, Grallert H, Glorioso N, Scott RA, Linneberg A, Kinnunen L, Sarti C, Collins FS, Lorentzon M, Hernandez D, Spector TD, Forrester T, Schurmann C, Hung J, Luben R, Zhang WH, Grammer TB, Smith JA, Middelberg RPS, Smith BH, Oldehinkel AJ, Bielak LF, Johnson AD, Boomsma DI, Jhun MA, Vink JM, Stringham HM, Ingelsson E, Marz W, Zillikens MC, Bakker SJL, North KE, Kramer BK, Gigante B, Jansson JO, Huang J, Kooner JS, Graff M, Bonnefond A, Kardia SLR, Jorgensen ME, Kahonen M, Vonk JM, Polasek O, Ong KK, Corre T, Vollenweider P, Morris AP, Perusse L, Gertow K, Hveem K, Tiemeier H, Franks PW, Slagboom PE, Zimmermann ME, Martin NG, Sanna S, Biffar R, Bottinger E, Ohlsson C, McKnight B, Czajkowski J, Hunter DJ, Stancakova A, Horikoshi M, van der Most PJ, Verweij N, Thuillier D, Komulainen P, Ridker PM, Boerwinkle E, Peyser PA, Waldenberger M, Ferrucci L, Van Vliet-Ostaptchouk JV, Chines PS, Van der Harst P, Staessen JA, Psaty BM, Delgado GE, Rose LM, Afaq S, Eriksson AL, Hartman CA, Boger CA, Beilby J, Grarup N, Adair LS, Young K, Mannikko R, Haiman CA, van Duijn CM, Sarzynski MA, Mueller-Nurasyid M, Ford I, Manichaikul A, Huang T, Rawal R, Amin N, Westendorp RGJ, Nolte IM, Wolffenbuttel BHR, Koistinen HA, Swertz MA, Wu J, Laakso M, Smith AV, Montgomery GW, Fischer K, Willemsen G, Wong A, Le Marchand L, Leander K, Blangero J, Whitfield JB, Ahmad S, Buyske S, Menni C, Cadby G, Gordon-Larsen P, Lupoli S, Vandenput L, Kanoni S, Kumari M, Braga D, Feitosa MF, den Ruijter HM, Jukema W, Sung YJ, Bouchard C, Hallmans G, Thorand B, Abecasis GR, Karlsson M, de Craen AJM, Vitart V, Porteous DJ, Siemelink MA, Qi QB, Lobbens S, Uitterlinden AG, Kolovou G, Tanaka T, McKenzie CA, Lubke G, Kooperberg C, Snieder H, Zhao JH, Ahluwalia TS, Homuth G, Luan J, Cucca F, Renstrom F, Lyytikainen LP, Huffman JE, Teumer A, Swift AJ, Yengo L, Mangino M, Wareham NJ, Sattar N, Lakka TA, Kuusisto J, Buckley BM, Ngwa JS, Trompet S, Kilpelainen TO, Tremoli E, de Geus EJC, Pedersen O, Vohl MC, Juonala M, Cooper RS, Coggeshall S, Bruinenberg M
المساهمون: tyks, vsshp, tyks, vsshp, sisätautioppi, Internal Medicine, sydäntutkimuskeskus, Research Centre of Applied and Preventive Cardiovascular Medicine (CAPC), 2607318, 2607004
بيانات النشر: NATURE PUBLISHING GROUP
United Kingdom
Britannia
GB
سنة النشر: 2022
المجموعة: University of Turku: UTUPub / Turun yliopisto
الوصف: Few genome-wide association studies (GWAS) account for environmental exposures, like smoking, potentially impacting the overall trait variance when investigating the genetic contribution to obesity-related traits. Here, we use GWAS data from 51,080 current smokers and 190,178 nonsmokers (87% European descent) to identify loci influencing BMI and central adiposity, measured as waist circumference and waist-to-hip ratio both adjusted for BMI. We identify 23 novel genetic loci, and 9 loci with convincing evidence of gene-smoking interaction (GxSMK) on obesity-related traits. We show consistent direction of effect for all identified loci and significance for 18 novel and for 5 interaction loci in an independent study sample. These loci highlight novel biological functions, including response to oxidative stress, addictive behaviour, and regulatory functions emphasizing the importance of accounting for environment in genetic analyses. Our results suggest that tobacco smoking may alter the genetic susceptibility to overall adiposity and body fat distribution.
نوع الوثيقة: other/unknown material
اللغة: English
تدمد: 2041-1723
العلاقة: ARTN 14977; Nature Communications; https://www.utupub.fi/handle/10024/164485Test; URN:NBN:fi-fe2021042716824
الإتاحة: https://www.utupub.fi/handle/10024/164485Test
رقم الانضمام: edsbas.36DBB583
قاعدة البيانات: BASE
الوصف
تدمد:20411723