التفاصيل البيبلوغرافية
| العنوان: |
Shared heritability and functional enrichment across six solid cancers |
| المؤلفون: |
Kim De Ruyck, Zsofia Kote-Jarai, Ruth C. Travis, Alfons Meindl, Miranda Pring, Anna Marie Mulligan, Karina Dalsgaard Sorensen, Trinidad Caldés, Stephanie Weinstein, D. Gareth Evans, Heinz-Josef Lenz, Marcia Cruz Correa, Sonja I. Berndt, Manolis Kogevinas, Flavio Lejbkowicz, Anna deFazio, Jenny Lester, Melinda C. Aldrich, M. Dawn Teare, Jonathan P. Tyrer, Kari Stefansson, Henrik Gronberg, Mark N. Brook, James D. Brenton, Kristin K. Zorn, Kenneth Muir, Robert L. Nussbaum, Adam S. Kibel, Austin Miller, Fergus J. Couch, Patricia A. Ganz, Jacques Simard, Wei Zheng, Gabriella Cadoni, Andrew F. Olshan, Michael Woods, Jeri Kim, Annika Lindblom, Marc T. Goodman, Thilo Dörk, Barbara Burwinkel, Robert Winqvist, Ulrike Peters, Carl Blomqvist, Hongbing Shen, Jeroen R. Huyghe, Lisa Cannon-Albright, Carolina Ellberg, Christopher A. Haiman, Rayjean J. Hung, Paolo Radice, Ana Vega, Christopher K. Edlund, Shelley S. Tworoger, Kathryn L. Penney, Hiltrud Brauch, Susanne M. Arnold, Drakoulis Yannoukakos, Mia M. Gaudet, Peter A. Fasching, Jenny L. Donovan, Rosa B. Barkardottir, Peter Hillemanns, Bogdan Pasaniuc, Heike Bickeböller, Digna R Velez Edwards, Karin Sundfeldt, Claudine Isaacs, Mark S. Goldberg, Manjeet K. Bolla, Darya Prokofyeva, Triantafillos Liloglou, Anna Jakubowska, Martha L. Slattery, Harvey A. Risch, Jan Lubiński, Eunjung Lee, Catherine M. Phelan, Mary Anne Rossing, Kay-Tee Khaw, Li Li, Roger L. Milne, Marc Tischkowitz, Stephanie L. Schmit, Orland Diez, Daniel D. Buchanan, Antonis C. Antoniou, Sue Ann Ingles, Kenneth Offit, José A. García-Sáenz, Joe Dennis, Brenda Diergaarde, Kristan J. Aronson, Edith Olah, Christopher I. Li, Karoline B. Kuchenbaecker, Robert L. Ferris, Lorelei Mucci, Nhu D. Le, Maria A. Caligo, David V. Conti, Davor Lessel, Paul D. P. Pharoah, Jong Y. Park, Andrew R. Ness, Gregory Idos, Jolanta Kupryjanczyk, Liene Nikitina-Zake, Jacek Gronwald, Maria Teresa Landi, Kjell Grankvist, Beth Y. Karlan, Aage Haugen, Vessela N. Kristensen, Sebastian Stintzing, Elisa V. Bandera, Stephen N. Thibodeau, Cornelia M. Ulrich, Fredrick R. Schumacher, Linda E. Kelemen, Emily White, Janet L. Stanford, Stella Koutros, Peter J. Hulick, Hans Brunnström, Lambertus A. Kiemeney, Victor Moreno, Corina Lesseur, Els Van Nieuwenhuysen, Taymaa May, Geoffrey Liu, Miguel Elías Aguado-Barrera, Graham G. Giles, Chu Chen, Cezary Cybulski, Jane C. Figueiredo, Dijana Plaseska-Karanfilska, Emmanouil Saloustros, Richa Saxena, Celine M. Vachon, Judy Garber, Richard Houlston, Penella Woll, Amanda B. Spurdle, Ute Hamann, David C. Christiani, Heli Nevanlinna, Niclas Håkansson, Eric J. Duell, David E. Goldgar, Ralf Butzow, John L. Hopper, Pascal Guénel, Johanna Schleutker, Robert J. MacInnis, Fredrik Wiklund, Peter Devilee, Younghun Han, Kirsten B. Moysich, Matthias W. Beckmann, Elinor J. Sawyer, Jochen Hampe, Hermann Brenner, Julia A. Knight, Victoria L. Stevens, Stephanie A. Bien, Hilary K. Finucane, Jyotsna Batra, Marjorie J. Riggan, Nawaid Usmani, Natalia V. Bogdanova, Catharine M. L. West, Kathleen B. M. Claes, Anthony J. Swerdlow, Ian Campbell, Mark H. Greene, Paul A. Townsend, Amanda I. Phipps, Peter Kraft, Xia Jiang, Michael T. Parsons, Duncan Thomas, Ali Amin Al Olama, Angela Cox, Loic Le Marchand, Miriam Dwek, Sara Margolin, Peter T. Campbell, Amanda E. Toland, Natalia N. Antonenkova, Hoda Anton-Culver, Kathryn L. Terry, Xifeng Wu, Judith Clements, Anna H. Wu, André L. Carvalho, Line Bjørge, Alice S. Whittemore, Penelope M. Webb, Susanne K. Kjaer, Irene L. Andrulis, Montserrat García-Closas, Douglas A. Levine, Olufunmilayo I. Olopade, Noralane M. Lindor, Michael Hoffmeister, Gary Goodman, V. Wendy Setiawan, Daniele Campa, Clarice R. Weinberg, Andrew K. Godwin, Alkes L. Price, Estrid Høgdall, Javier Benitez, David G. Huntsman, Katherine L. Nathanson, Stephen B. Gruber, Mikael Johansson, Tanja Pejovic, Wilbert H M. Peters, Mary Beth Terry, Rebecca Sutphen, Banu K. Arun, Mark A. Jenkins, Lesley McGuffog, Håkan Olsson, Goska Leslie, Andrew Berchuck, Francesmary Modugno, Frank Claessens, Douglas F. Easton, Philip Lazarus, Manuela Gago-Dominguez, Pooja Middha, Diether Lambrechts, Matthew B. Schabath, Lisa F. Newcomb, Evgeny N. Imyanitov, Daniel R. Barnes, Dale P. Sandler, Demetrius Albanes, Christian F. Singer, Nora Pashayan, Paul James, Alicja Wolk, Rosalind A. Eeles, Gad Rennert, Stephan Lam, Florian Heitz, Weiva Sieh, Joan Brunet, David E. Neal, H-Erich Wichmann, Kamila Czene, Freddie C. Hamdy, Nadine Tung, Barry S. Rosenstein, Melissa C. Southey, Shanbeh Zienolddiny, Fotios Loupakis, Monique J. Roobol, Angela Risch, Arto Mannermaa, Neil Caporaso, Kyriaki Michailidou, Olivia Fletcher, Sara Lindström, Graham Casey, Christiane Maier, Mary B. Daly, Stefania Boccia, Hedy S. Rennert, Tabea Kühl, Marjanka K. Schmidt, Georgia Chenevix-Trench, Martin Lacko, J. Margriet Collée, Radka Kaneva, Catherine M. Tangen, David J. Hunter, Lovise Maehle, Andrew T. Chan, Adonina Tardon, Simon A. Gayther, Jeffrey N. Weitzel, Argyrios Ziogas, Géraldine Cancel-Tassin, Elizabeth J. van Rensburg, James McKay, Diana Torres, Li Hsu, Susan L. Neuhausen, Jack A. Taylor, Finn Cilius Nielsen, Eitan Friedman, Diana M. Eccles, Per Hall, Marco Montagna, Ellen L. Goode, Julie M. Cunningham, Amit D. Joshi, Erin M. Siegel, Renée T. Fortner, Jenny Chang-Claude, Steven J. Gallinger, Jennifer Stone, Esther M. John, Elza Khusnutdinova, Ana Osorio, Stephen J. Chanock, Rolando Herrero, Stig E. Bojesen, Alison M. Dunning, Leon Raskin, Robert J. Hamilton, Qin Wang, Christopher I. Amos, Polly A. Newcomb, Mark C. Weissler, Manuel R. Teixeira, Yun-Chul Hong, Paul J. Brennan, Mattias Johansson, Børge G. Nordestgaard, Mads Thomassen, Florentia Fostira, Sara Benlloch, Eloiza H. Tajara, Jacqueline M. Lane, Silvia Franceschi, Susan J. Ramus, Hardev Pandha, Angeline S. Andrew |
| المساهمون: |
tyks, vsshp, tyks, vsshp, biolääketieteen laitos, yhteiset, Institute of Biomedicine, 2607100 |
| بيانات النشر: |
NATURE PUBLISHING GROUP
United Kingdom
Britannia
GB |
| سنة النشر: |
2022 |
| المجموعة: |
University of Turku: UTUPub / Turun yliopisto |
| الوصف: |
Quantifying the genetic correlation between cancers can provide important insights into the mechanisms driving cancer etiology. Using genome-wide association study summary statistics across six cancer types based on a total of 296,215 cases and 301,319 controls of European ancestry, here we estimate the pair-wise genetic correlations between breast, colorectal, head/neck, lung, ovary and prostate cancer, and between cancers and 38 other diseases. We observed statistically significant genetic correlations between lung and head/neck cancer (r(g) = 0.57, p = 4.6 x 10(-8)), breast and ovarian cancer (r(g) = 0.24, p = 7 x 10(-5)), breast and lung cancer (r(g) = 0.18, p = 1.5 x 10(-6)) and breast and colorectal cancer (r(g) = 0.15, p = 1.1 x 10(-4)). We also found that multiple cancers are genetically correlated with non-cancer traits including smoking, psychiatric diseases and metabolic characteristics. Functional enrichment analysis revealed a significant excess contribution of conserved and regulatory regions to cancer heritability. Our comprehensive analysis of cross-cancer heritability suggests that solid tumors arising across tissues share in part a common germline genetic basis. |
| نوع الوثيقة: |
other/unknown material |
| اللغة: |
English |
| تدمد: |
2041-1723 |
| العلاقة: |
10; ARTN 431; Nature Communications; https://www.utupub.fi/handle/10024/157940Test; URN:NBN:fi-fe2021042823271 |
| الإتاحة: |
https://www.utupub.fi/handle/10024/157940Test |
| رقم الانضمام: |
edsbas.B7C9486D |
| قاعدة البيانات: |
BASE |
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