Evaluation of Prognostic Significance of the International Staging System According to Glomerular Filtration Rate in Newly Diagnosed Multiple Myeloma Patients Eligible for Autologous Stem Cell Transplantation
| العنوان: | Evaluation of Prognostic Significance of the International Staging System According to Glomerular Filtration Rate in Newly Diagnosed Multiple Myeloma Patients Eligible for Autologous Stem Cell Transplantation |
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| المؤلفون: | Osman Özcebe, Salih Aksu, Ibrahim C. Haznedaroglu, Hakan Goker, Yahya Buyukasik, Rafiye Ciftciler, Haluk Demiroglu, Nilgun Sayinalp |
| المصدر: | Turkish Journal of Hematology, Vol 38, Iss 1, Pp 33-40 (2021) Turkish Journal of Hematology |
| بيانات النشر: | Galenos Yayinevi, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Adult, Male, 0301 basic medicine, medicine.medical_specialty, lcsh:Internal medicine, health care facilities, manpower, and services, Clinical Decision-Making, Urology, Renal function, Newly diagnosed, urologic and male genital diseases, Transplantation, Autologous, 03 medical and health sciences, 0302 clinical medicine, Autologous stem-cell transplantation, health services administration, Humans, Medicine, Stage (cooking), lcsh:RC31-1245, Staging system, Multiple myeloma, Aged, Neoplasm Staging, Proportional Hazards Models, Retrospective Studies, business.industry, Beta-2 microglobulin, lcsh:RC633-647.5, Hematopoietic Stem Cell Transplantation, Disease Management, Induction chemotherapy, Hematology, lcsh:Diseases of the blood and blood-forming organs, Middle Aged, Prognosis, medicine.disease, Survival Analysis, international staging system, multiple myeloma, 030104 developmental biology, 030220 oncology & carcinogenesis, b2-microglobulin, Female, business, human activities, Biomarkers, Glomerular Filtration Rate, Research Article |
| الوصف: | The prognosis of multiple myeloma (MM) patients is highly heterogeneous. The aim of this study is to determine the impact of patients’ renal functions on the prognostic performance of the International Staging System (ISS). In addition, we aimed to evaluate the results of survival of patients with ISS stages and normal renal functions and those with ISS stages and abnormal renal functions with this study.Two hundred and four patients with newly diagnosed MM who received an autologous stem cell transplantation after induction chemotherapy in our tertiary care center between the years of 2001 and 2018 were evaluated.There were 153 (75%) MM patients who had a glomerular filtration rate (GFR) of ≥60 mL/min and 51 (25%) MM patients who had GFR of60 mL/min at the time of diagnosis in this study. There was a strong correlation between ISS stage and GFR. The ISS stages were higher in patients who had GFR of60 mL/min than patients who had GFR of ≥60 mL/min (p0.001). Patients with GFR of60 mL/min were significantly more prevalent in the ISS III group than ISS I and II (p0.001).This study showed that the ISS provides significant prognostic information in MM patients with GFR of ≥60 mL/min at diagnosis. However, in patients with impaired renal function at the time of diagnosis, B2-microglobulin may not be a good prognostic indicator since it may be affected by renal dysfunction as well as tumor burden.Multipl miyelom (MM) hastalarının prognozu oldukça heterojendir. Bu çalışmanın amacı, hastaların böbrek fonksiyonlarının Uluslararası Evreleme Sistemi’nin (ISS) prognostik performansı üzerindeki etkisini belirlemektir. Ayrıca bu çalışma ile ISS evreli ve böbrek fonksiyonları normal ve anormal olan hastaların ISS evresine göre sağkalım sonuçlarını değerlendirmeyi amaçladık.2001-2018 yılları arasında üçüncü basamak merkezimizde indüksiyon kemoterapisi sonrası otolog kök hücre nakli yapılan yeni tanı konmuş MM’li 244 hasta değerlendirildi.Tanı anında glomerüler filtrasyon hızı (GFR) ≥60 mL/dak olan 153 (%75) MM hastası ve GFR’si60 mL/dak olan 51 (%25) MM hastası vardı. ISS evresi ile GFR arasında güçlü bir ilişki vardı. ISS evreleri, GFR değeri60 mL/dak olan hastalarda GFR’si ≥60 mL/dak olan hastalara göre daha yüksekti (p0,001). GFR değeri60 mL/dak olan hasta sayısı, ISS 3 grubunda ISS 1 ve 2’ye göre anlamlı olarak daha saptandı (p0,001).Bu çalışma, ISS’nin GFR’si ≥60 mL/dak olan MM hastalarında tanıda önemli prognostik bilgi sağladığını göstermiştir. Bununla birlikte, tanı anında böbrek fonksiyon bozukluğu olan hastalarda B2-mikroglobulin, böbrek fonksiyon bozukluğundan ve tümör yükünden etkilenebileceğinden iyi bir prognostik gösterge olmayabilir. |
| اللغة: | English |
| تدمد: | 1308-5263 1300-7777 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::443f0f5b15c47a1f580dbe826fc42ba8Test https://jag.journalagent.com/tjh/pdfs/TJH_38_1_33_40.pdfTest |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....443f0f5b15c47a1f580dbe826fc42ba8 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 13085263 13007777 |
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