دورية أكاديمية
Antinuclear, Cytoskeletal, Antineuronal Antibodies in the Serum Samples of Children with Tic Disorders and Obsessive Compulsive Disorders
| العنوان: | Antinuclear, Cytoskeletal, Antineuronal Antibodies in the Serum Samples of Children with Tic Disorders and Obsessive Compulsive Disorders |
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| المؤلفون: | Işık Görker, Gülşen Akman Demir, Nuray Gürel Polat, Rukiye Eker Ömeroğlu, Sema İçöz, Piraye Serdaroğlu, Ümran Tüzün |
| المصدر: | Balkan Medical Journal, Vol 28, Iss 04, Pp 440-444 (2011) |
| بيانات النشر: | Galenos Publishing House, 2011. |
| سنة النشر: | 2011 |
| المجموعة: | LCC:Medicine |
| مصطلحات موضوعية: | Tic disorders, obsessive compulsive disorder, PANDAS, autoimmunity, child, Medicine |
| الوصف: | streptococcus infections in the development of tic and obsessive compulsive disorders (OCD) is controversial. The autoimmune hypothesis states that during infection, formation of autoantibodies leads to an autoimmune disorder, which in turn results in movement disorders, tic disorders and/or OCD. In order to test this hypothesis, we assayed these antibodies in children and adolescents diagnosed with tic disorders and/or OCD.Material and Methods: Children and adolescents who were diagnosed with either tic disorders or OCD according to DSM-IV criteria (n=28), were compared with healthy controls (n=15) having similar age and gender characteristics. Regardless of a streptococcus infection history, serum samples of all patients and controls underwent antinuclear, cytoskeletal, and antineuronal antibody assay using indirect immunofluorescence.Results: The rates of antinuclear antibody positivity were 21% and 20% in the patient and control groups respectively (p>0.05). Antineuronal antibody was positive in 2 (7%) of 28 patients versus in 1 (6%) of 15 controls (p>0.05).Conclusion: These results suggest that such antibodies may not be involved in the pathogenesis of tic disorders/OCD. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2146-3123 2146-3131 |
| العلاقة: | http://balkanmedicaljournal.org/text.php3?id=809Test; https://doaj.org/toc/2146-3123Test; https://doaj.org/toc/2146-3131Test |
| الوصول الحر: | https://doaj.org/article/1115b20e37d84c77af7c10a7a83caca5Test |
| رقم الانضمام: | edsdoj.1115b20e37d84c77af7c10a7a83caca5 |
| قاعدة البيانات: | Directory of Open Access Journals |
| تدمد: | 21463123 21463131 |
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