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Prognostic value of circulating endothelial cells in glioblastoma patients: a pilot study

التفاصيل البيبلوغرافية
العنوان: Prognostic value of circulating endothelial cells in glioblastoma patients: a pilot study
المؤلفون: María Angeles Vaz Salgado, Julie Earl, Victor Rodriguez Berrocal, Freddy Salge Arrieta, Ana Gomez, Juan Manuel Sepulveda-Sanchez, Ángel Perez-Nuñez, Elena Corral de la Fuente, Daniel Lourido, MaríaVillamayor, Hector Pian, Alfonso Muriel, Elisabetta Rossi, Rita Zamarchi, Alfredo Carrato, Luis Ley
المصدر: Future Science OA, Vol 8, Iss 5 (2022)
بيانات النشر: Future Science Ltd
سنة النشر: 2022
المجموعة: Directory of Open Access Journals: DOAJ Articles
مصطلحات موضوعية: biomarker, circulating endothelial cells (CECs), glioblastoma, perfusion MRI, Medicine, Medicine (General), R5-920
الوصف: Aim: Glioblastoma (GB) is an aggressive tumor type and the detection of circulating endothelial cells (CECs) in peripheral blood has been related to angiogenesis. Materials & methods: A prospective single-center pilot study of CEC detection at diagnosis in 22 patients with GB was performed, using the US FDA-approved CellSearch system. Results: A CEC cutoff value was estimated using a receiver operating curve (ROC) and patients were classified into two groups: <40 CEC/4 ml and >40 CEC/4 ml blood. Median overall survival was 25.33 months for group 1 and 8.23 months for group 2 cases (p = 0.02). There was no correlation between CEC and PWI (perfusion-weighted imaging) RM. Conclusion: CEC detection has a prognostic value in GB cases at diagnosis.
نوع الوثيقة: article in journal/newspaper
اللغة: English
تدمد: 2056-5623
العلاقة: https://doaj.org/toc/2056-5623Test; https://doaj.org/article/10cbeb6d83ca4bf8842cb0bb7fc1e6a4Test
DOI: 10.2144/fsoa-2022-0008
الإتاحة: https://doi.org/10.2144/fsoa-2022-0008Test
https://doaj.org/article/10cbeb6d83ca4bf8842cb0bb7fc1e6a4Test
رقم الانضمام: edsbas.400F10AF
قاعدة البيانات: BASE
الوصف
تدمد:20565623
DOI:10.2144/fsoa-2022-0008