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Exploring the role of cerebrospinal fluid as analyte in neurologic disorders

التفاصيل البيبلوغرافية
العنوان: Exploring the role of cerebrospinal fluid as analyte in neurologic disorders
المؤلفون: Sandeep C Pingle, Feng Lin, Misa S Anekoji, C Pawan K Patro, Souvik Datta, Lawrence D Jones, Santosh Kesari, Shashaanka Ashili
المصدر: Future Science OA, Vol 9, Iss 4 (2023)
بيانات النشر: Future Science Ltd
سنة النشر: 2023
المجموعة: Directory of Open Access Journals: DOAJ Articles
مصطلحات موضوعية: biomarkers, cerebrospinal fluid, circulating cells, genomics, malignancy, neurodegenerative disorders, Medicine, Medicine (General), R5-920
الوصف: The cerebrospinal fluid (CSF) is a clear ultrafiltrate of blood that envelopes and protects the central nervous system while regulating neuronal function through the maintenance of interstitial fluid homeostasis in the brain. Due to its anatomic location and physiological functions, the CSF can provide a reliable source of biomarkers for the diagnosis and treatment monitoring of different neurological diseases, including neurodegenerative diseases such as Alzheimer's disease, Parkinson's disease, amyotrophic lateral sclerosis, and primary and secondary brain malignancies. The incorporation of CSF biomarkers into the drug discovery and development can improve the efficiency of drug development and increase the chances of success. This review aims to consolidate the current use of CSF biomarkers in clinical practice and explore future perspectives for the field.
نوع الوثيقة: article in journal/newspaper
اللغة: English
تدمد: 2056-5623
العلاقة: https://doaj.org/toc/2056-5623Test; https://doaj.org/article/4a5fa54ebd54428da53f363a8a092fadTest
DOI: 10.2144/fsoa-2023-0006
الإتاحة: https://doi.org/10.2144/fsoa-2023-0006Test
https://doaj.org/article/4a5fa54ebd54428da53f363a8a092fadTest
رقم الانضمام: edsbas.F54A2ACA
قاعدة البيانات: BASE
الوصف
تدمد:20565623
DOI:10.2144/fsoa-2023-0006