دورية أكاديمية
Poly(lactic acid) and poly(lactic-co-glycolic acid) particles as versatile carrier platforms for vaccine delivery.
| العنوان: | Poly(lactic acid) and poly(lactic-co-glycolic acid) particles as versatile carrier platforms for vaccine delivery. |
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| المؤلفون: | Pavot, V, Berthet, M, Rességuier, J, Legaz, S, Handké, N, Gilbert, S, Paul, S, Verrier, B |
| بيانات النشر: | Future Medicine Ltd. |
| سنة النشر: | 2016 |
| المجموعة: | Oxford University Research Archive (ORA) |
| الوصف: | The development of safe and effective vaccines for cancer and infectious diseases remains a major goal in public health. Over the last two decades, controlled release of vaccine antigens and immunostimulant molecules has been achieved using nanometer or micron-sized delivery vehicles synthesized using biodegradable polymers. In addition to achieving a depot effect, enhanced vaccine efficacy using such delivery vehicles has been attributed to efficient targeting of antigen presenting cells such as dendritic cells. Biodegradable and biocompatible poly(lactic acid) and poly(lactic-co-glycolic acid) polymers belong to one such family of polymers that have been a popular choice of material used in the design of these delivery vehicles. This review summarizes research findings from ourselves and others highlighting the promise of poly(lactic acid)- and poly(lactic-co-glycolic acid)-based vaccine carriers in enhancing immune responses. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | https://ora.ox.ac.uk/objects/uuid:50e200bf-7a4a-4c29-9d7f-0110acd4e538Test; https://doi.org/10.2217/nnm.14.156Test |
| DOI: | 10.2217/nnm.14.156 |
| الإتاحة: | https://doi.org/10.2217/nnm.14.156Test https://ora.ox.ac.uk/objects/uuid:50e200bf-7a4a-4c29-9d7f-0110acd4e538Test |
| حقوق: | info:eu-repo/semantics/embargoedAccess |
| رقم الانضمام: | edsbas.611EBCB7 |
| قاعدة البيانات: | BASE |
| DOI: | 10.2217/nnm.14.156 |
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