Effective personalized neoantigen vaccine plus anti-PD-1 in a PD-1 blockade-resistant lung cancer patient
| العنوان: | Effective personalized neoantigen vaccine plus anti-PD-1 in a PD-1 blockade-resistant lung cancer patient |
|---|---|
| المؤلفون: | Song Gao, Jiaqian Wang, Zhongzheng Zhu, Juemin Fang, Yu Zhao, Zhuqing Liu, Huanlong Qin, Yuquan Wei, Heng Xu, Xu Dan, Li Yang, Qing Xu |
| المصدر: | Immunotherapy. 15:57-69 |
| بيانات النشر: | Future Medicine Ltd, 2023. |
| سنة النشر: | 2023 |
| مصطلحات موضوعية: | Oncology, Immunology, Immunology and Allergy |
| الوصف: | Background: Although significant progress has been made in immune checkpoint inhibitor (ICI) treatment of advanced squamous cell carcinoma (SqCC), most patients still experience acquired drug resistance. Methods: We used a dendritic cell-based neoantigen vaccine combined with ICIs to treat advanced SqCC in a PD-1 blockade-resistant patient. Results: The follow-up of this patient after 12 months revealed significant tumor regression. We also identified a new JAK1 ICI-resistant mutation that could become a potential universal neoantigen target for tumor vaccines. Conclusion: Individualized management of advanced SqCC through a combined neoantigen vaccine and ICI administration could yield beneficial clinical outcomes. Vaccines targeting anti-PD-1-resistant JAK1 mutations might be of particular benefit to a specific group of solid tumor patients. |
| تدمد: | 1750-7448 1750-743X |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_________::ac09109301641296977131cffb18a367Test https://doi.org/10.2217/imt-2021-0339Test |
| رقم الانضمام: | edsair.doi...........ac09109301641296977131cffb18a367 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 17507448 1750743X |
|---|