التفاصيل البيبلوغرافية
| العنوان: |
A randomized phase II study comparing preoperative mFOLFOX6 versus FOLFOXIRI for locally advanced colon cancer: JCOG2006. |
| المؤلفون: |
Hashimoto, Tadayoshi, Maruyama, Satoshi, Takii, Yasumasa, Mizusawa, Junki, Kataoka, Tomoko, Fukuda, Haruhiko, Tsukamoto, Shunsuke, Takashima, Atsuo, Hamaguchi, Tetsuya, Kanemitsu, Yukihide |
| المصدر: |
Future Oncology; Sep2023, Vol. 19 Issue 28, p1897-1904, 8p |
| مستخلص: |
The prognosis of locally advanced colon cancer (LACC) with surgical resection followed only by adjuvant chemotherapy is poor. Preoperative chemotherapy for LACC patients with risk factors such as cT4bN+ or cT3-4aN2-3 has attracted attention. Here, the authors describe the rationale and design of JCOG2006, a randomized phase II study comparing preoperative chemotherapy with mFOLFOX6 versus FOLFOXIRI for LACC. Their efficacy and safety are evaluated and a determination of which is the more promising treatment will be conducted in a subsequent phase III trial. A total of 86 patients will be accrued from 44 institutions over 2 years. The primary end point is the proportion of patients with a Tumor Regression Score of 0–2, and secondary end points include overall survival, response rate and adverse events. Clinical Trial Registration: jRCTs031210365 (https://jrct.niph.go.jpTest/) A randomized phase II selection design trial for resectable locally advanced colon cancer to determine whether mFOLFOX6 or FOLFOXIRI is more promising for a subsequent phase III trial. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
