دورية أكاديمية
Expression study of candidate miRNAs and evaluation of their potential use as biomarkers of diabetic neuropathy
| العنوان: | Expression study of candidate miRNAs and evaluation of their potential use as biomarkers of diabetic neuropathy |
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| المؤلفون: | Ciccacci, Cinzia, Latini, Andrea, Colantuono, Antonella, Politi, Cristina, D'Amato, Cinzia, Greco, Carla, Rinaldi, Maria Elena, Lauro, Davide, Novelli, Giuseppe, Spallone, Vincenza, Borgiani, Paola |
| المساهمون: | Ciccacci, C, Latini, A, Colantuono, A, Politi, C, D'Amato, C, Greco, C, Rinaldi, Me, Lauro, D, Novelli, G, Spallone, V, Borgiani, P |
| بيانات النشر: | FUTURE MEDICINE LTD |
| سنة النشر: | 2020 |
| المجموعة: | Universitá degli Studi di Roma "Tor Vergata": ART - Archivio Istituzionale della Ricerca |
| مصطلحات موضوعية: | diabetic neuropathy, expression study, microRNAs, Settore MED/03 - GENETICA MEDICA |
| الوصف: | Aim: To evaluate the expression of candidate miRNAs in relation to diabetic polyneuropathy (DPN) and cardiovascular autonomic neuropathy (CAN). Materials & methods: The expression of six candidate miRNAs has been evaluated in 49 Type 2 diabetes patients with neurological evaluation. Results: A higher expression of miR-128a was seen in patients with DPN compared with those without DPN (p = 0.015). miR-155 and miR-499a seemed to be down-expressed in patients with DPN (p = 0.04 and p = 0.05, respectively). A lower expression of miR-155 (p = 0.05) was observed even in patients with CAN with respect to CAN-negative. A higher expression of miR-155 was associated with the rs767649 polymorphism variant allele compared with the wild-type allele (p = 0.03). Conclusion: miR-128a, miR-155 and miR-499a might be involved in diabetic neuropathies development. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | info:eu-repo/semantics/altIdentifier/pmid/32400192; info:eu-repo/semantics/altIdentifier/wos/WOS:000569914400003; volume:12; issue:7; firstpage:575; lastpage:585; numberofpages:11; journal:EPIGENOMICS; http://hdl.handle.net/2108/257158Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85088201824 |
| DOI: | 10.2217/epi-2019-0242 |
| الإتاحة: | https://doi.org/10.2217/epi-2019-0242Test http://hdl.handle.net/2108/257158Test |
| حقوق: | info:eu-repo/semantics/restrictedAccess |
| رقم الانضمام: | edsbas.93AE4136 |
| قاعدة البيانات: | BASE |
| DOI: | 10.2217/epi-2019-0242 |
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