Critical evaluation of the DNA-methylation markers ABCG1 and SREBF1 for Type 2 diabetes stratification
| العنوان: | Critical evaluation of the DNA-methylation markers ABCG1 and SREBF1 for Type 2 diabetes stratification |
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| المؤلفون: | Hendrik Lehnert, Olena Ohlei, Meike Kasten, Henriette Kirchner, Stefan Wolter, Oliver Mann, Christine Klein, Fabian Kilpert, Georg Brabant, Helen Sievert, Martina Grohs, Cathleen Geißler, Alexander T. El Gammal, Ulrike M. Krämer, Christin Krause |
| المصدر: | Epigenomics. 11:885-897 |
| بيانات النشر: | Future Medicine Ltd, 2019. |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | Genetic Markers, 0301 basic medicine, Oncology, Cancer Research, medicine.medical_specialty, Adipose tissue, Type 2 diabetes, 03 medical and health sciences, 0302 clinical medicine, Diabetes mellitus, Internal medicine, Genetics, medicine, Humans, Insulin, SNP, ATP Binding Cassette Transporter, Subfamily G, Member 1, Genetic association, biology, Methylation, DNA Methylation, medicine.disease, 030104 developmental biology, Diabetes Mellitus, Type 2, ABCG1, 030220 oncology & carcinogenesis, DNA methylation, biology.protein, Sterol Regulatory Element Binding Protein 1 |
| الوصف: | Aim: Validation of epigenome-wide association studies is sparse. Therefore, we evaluated the methylation markers cg06500161 ( ABCG1) and cg11024682 ( SREBF1) as classifiers for diabetes stratification. Patients & methods: DNA methylation was measured in blood (n = 167), liver (n = 99) and visceral adipose tissue (n = 99) of nondiabetic or Type 2 diabetic subjects by bisulfite pyrosequencing. Results: DNA methylation at cg11024682 in blood and liver correlated with BMI. Methylation at cg06500161 was influenced by the adjacent SNP rs9982016. Insulin-resistant and sensitive subjects could be stratified by DNA methylation status in blood or visceral adipose tissue. Conclusion: DNA methylation at both loci in blood presents a promising approach for risk group stratification and could be valuable for personalized Type 2 diabetes risk prediction in the future. |
| تدمد: | 1750-192X 1750-1911 0650-0161 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::95d20aee6870fe2d76521c2f57a1a74bTest https://doi.org/10.2217/epi-2018-0159Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....95d20aee6870fe2d76521c2f57a1a74b |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 1750192X 17501911 06500161 |
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