HLA genes as modifiers of response to IFN-β-1a therapy in relapsing-remitting multiple sclerosis
| العنوان: | HLA genes as modifiers of response to IFN-β-1a therapy in relapsing-remitting multiple sclerosis |
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| المؤلفون: | Mehrdokht Mazdeh, Ghasem Solgi, Mohammad Esmaeil Akbari, Hidetoshi Inoko, Mohammad Taheri, Abolfazl Movafagh, Arezou Sayad, Rezvan Noroozi, Siamak Bahram, Mir Davood Omrani, Mehrdad Hajilooi |
| المصدر: | Pharmacogenomics. 17:489-498 |
| بيانات النشر: | Future Medicine Ltd, 2016. |
| سنة النشر: | 2016 |
| مصطلحات موضوعية: | Adult, Male, 0301 basic medicine, Hla genes, Human leukocyte antigen, 03 medical and health sciences, Multiple Sclerosis, Relapsing-Remitting, 0302 clinical medicine, Genetics, medicine, Humans, Prospective Studies, Allele, Gene, Pharmacology, Expanded Disability Status Scale, HLA-A Antigens, business.industry, Multiple sclerosis, Haplotype, medicine.disease, 030104 developmental biology, Haplotypes, HLA-B Antigens, Case-Control Studies, Immunology, Cohort, Molecular Medicine, Female, business, Interferon beta-1a, 030217 neurology & neurosurgery, HLA-DRB1 Chains |
| الوصف: | Aims: This study investigated the influence of HLA class-I and -II genes in the response to IFN-β in relapsing-remitting multiple sclerosis (MS) patients. Patients & methods: In this cohort, 231 relapsing-remitting MS patients who are classified into IFN-β responders (n = 146) and nonresponders (n = 85) and 180 ethnic-matched healthy controls were analyzed. Clinical outcome of IFN-β therapy particularly Expanded Disability Status Scale scores were evaluated in relation to HLA-A, -B and -DRB1 alleles and haplotypes. Results: Increased frequencies of HLA-DRB1*04 allele and HLA-A*03-B*44-DRB1*04 haplotype, and decreased frequency of HLA-B*15 were associated with better response to IFN-β treatment. Conclusion: The possibility of genetic screening particularly HLA typing prior to starting IFN-β therapy for MS may permit the identification of likely responders or nonresponders. |
| تدمد: | 1744-8042 1462-2416 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::33a1337416f7b603e2f3df297f96b0f1Test https://doi.org/10.2217/pgs.16.2Test |
| رقم الانضمام: | edsair.doi.dedup.....33a1337416f7b603e2f3df297f96b0f1 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 17448042 14622416 |
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