التفاصيل البيبلوغرافية
| العنوان: |
Biomarkers in osteoarthritis: a clinical trials perspective. |
| المؤلفون: |
Jordan, Joanne M., Kraus, Virginia B. |
| المصدر: |
Future Rheumatology; Oct2006, Vol. 1 Issue 5, p587-596, 10p |
| مصطلحات موضوعية: |
OSTEOARTHRITIS, ARTHRITIS, OBESITY, BIOMARKERS, CLINICAL trials |
| مستخلص: |
Osteoarthritis (OA), the most common type of arthritis, causes considerable disability and a significant public health impact. The burden of OA will increase with aging of the population and the present obesity epidemic. Currently, potential structure-modifying drugs for OA must demonstrate slowing of the rate of joint space narrowing in serial radiographs. This usually requires clinical trials of 2-3 years duration. More sensitive and precise biomarkers can potentially aid selection of participants into trials, identify those at highest risk of rapid disease progression and provide new surrogate markers for radiographic OA. These biomarkers will decrease the cost and duration of trials, and hasten the development and approval of new disease-modifying pharmaceuticals. Standardization of assays, methods of specimen collection and assessment of marker variation by age, race/ethnicity, sex, body mass index, total body OA load, comorbid conditions and medications will continue to be evaluated to hasten the incorporation of biomarkers into clinical trial design. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
