First endocavitary treatment with cord blood platelet gel for perianal fistula
| العنوان: | First endocavitary treatment with cord blood platelet gel for perianal fistula |
|---|---|
| المؤلفون: | Nicola Mastrodonato, Filomena Urbano, Lazzaro Di Mauro, Giovanni Bisceglia, Francesca Bazzocchi, A. Totaro, Augusta Faienza, Michele Santodirocco |
| المصدر: | Regenerative Medicine. 15:1171-1176 |
| بيانات النشر: | Future Medicine Ltd, 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | Blood Platelets, Embryology, medicine.medical_specialty, Pathology, Biomedical Engineering, 030204 cardiovascular system & hematology, 03 medical and health sciences, 0302 clinical medicine, Perianal fistula, In vivo, Internal medicine, medicine, Humans, Rectal Fistula, Platelet, Platelet concentrate, 030304 developmental biology, Wound Healing, 0303 health sciences, Hematology, Chemistry, Middle Aged, Fetal Blood, Prognosis, Clot formation, Coagulation, Cord blood, Intercellular Signaling Peptides and Proteins, Female, Gels |
| الوصف: | Cord blood platelet gel is prepared by activation of coagulation in a platelet concentrate obtained from cord blood. During the process of clot formation, platelet alpha-granules release growth factors that promote tissue repair. However, in the form of gel, it is not possible to inject it into small, narrow and deep cavities. Therefore, we analyzed gelification kinetics and developed an application technique of platelet gel in liquid form. This semi-activated form provides for the activation of the coagulation process but not the gelification of the platelet concentrate. In this way, it can be easily inoculated in an endocavitary space, and then complete in vivo the gelification process. We report the successful use of this procedure to heal a recurrent perianal fistula. |
| تدمد: | 1746-076X 1746-0751 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ff6bfaff0ace2277d8afc11e0e36846aTest https://doi.org/10.2217/rme-2019-0074Test |
| رقم الانضمام: | edsair.doi.dedup.....ff6bfaff0ace2277d8afc11e0e36846a |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 1746076X 17460751 |
|---|