التفاصيل البيبلوغرافية
| العنوان: |
Comparative effectiveness of torsemide versus furosemide in heart failure patients: insights from the PROTECT trial. |
| المؤلفون: |
Mentz, Robert J, Velazquez, Eric J, Metra, Marco, McKendry, Colleen, Chiswell, Karen, Fiuzat, Mona, Givertz, Michael M, Voors, Adriaan A, Teerlink, John R, O'Connor, Christopher M |
| المصدر: |
Future Cardiology; Sep2015, Vol. 11 Issue 5, p585-595, 11p |
| مستخلص: |
Aim: The authors assessed the comparative effectiveness of torsemide versus furosemide in the PROTECT trial.Methods: The authors assessed the relationship between loop diuretic at discharge and death or cardiovascular/renal hospitalization within 30 days, and death through 150 days postdischarge using inverse probability weighting.Results: Out of 1004 patients, 83.5% received furosemide and 16.5% torsemide. Torsemide patients had higher blood urea nitrogen, and more in-hospital worsening heart failure. Following adjustment, torsemide was associated with similar 30-day outcomes compared with furosemide (p = 0.93), but remained associated with increased 150-day death (hazard ratio: 2.26; 95% CI: 1.40-3.66; p < 0.001).Conclusion: Patients treated with torsemide had features of greater disease severity, similar 30-day outcomes but increased 150-day mortality. Prospective randomized trials are needed to investigate the effect of torsemide versus furosemide. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
