Molecular background of oligodendroglioma: 1p/19q, IDH, TERT, CIC and FUBP1
| العنوان: | Molecular background of oligodendroglioma: 1p/19q, IDH, TERT, CIC and FUBP1 |
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| المؤلفون: | John Gregory Cairncross, David N. Louis, Daniel P. Cahill |
| المصدر: | CNS Oncology. 4:287-294 |
| بيانات النشر: | Future Medicine Ltd, 2015. |
| سنة النشر: | 2015 |
| مصطلحات موضوعية: | Epigenomics, Pathology, medicine.medical_specialty, Telomerase, IDH1, Oligodendroglioma, Brain tumor, Review, medicine.disease_cause, Chromosome 19, medicine, Humans, ATRX, Mutation, Brain Neoplasms, business.industry, DNA Helicases, Disease Management, RNA-Binding Proteins, Chromosome, General Medicine, medicine.disease, Isocitrate Dehydrogenase, DNA-Binding Proteins, Repressor Proteins, Chromosomes, Human, Pair 1, Chromosome Deletion, business, Chromosomes, Human, Pair 19 |
| الوصف: | Oligodendroglioma is the quintessential molecularly-defined brain tumor. The characteristic whole-arm loss of the long arm of chromosome 1 and the short arm of chromosome 19 (1p/19q-codeletion) within the genome of these tumors facilitated the reproducible molecular identification of this subcategory of gliomas. More recently, recurrent molecular genetic alterations have been identified to occur concurrently with 1p/19q-codeletion, and definitively identify these tumors, including mutations in IDH1/2, CIC, FUBP1, and the TERT promoter, as well as the absence of ATRX and TP53 alterations. These findings provide a foundation for the consistent diagnosis of this tumor type, upon which a generation of clinical investigators have assembled a strong evidence base for the effective treatment of this disease with radiation and chemotherapy. |
| تدمد: | 2045-0915 2045-0907 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bf8a2b6451984e97372d53d591630184Test https://doi.org/10.2217/cns.15.32Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....bf8a2b6451984e97372d53d591630184 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 20450915 20450907 |
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