Comparison of primary breast cancer and paired metastases: biomarkers discordance influence on outcome and therapy
| العنوان: | Comparison of primary breast cancer and paired metastases: biomarkers discordance influence on outcome and therapy |
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| المؤلفون: | Lorenzo Gerratana, Elena Poletto, Carla Di Loreto, Marika Cinausero, Manuela Giangreco, Fabio Puglisi, Alessandro Marco Minisini, Stefano Pizzolitto, Elena Ongaro, Giacomo Pelizzari, Stefania Russo, Claudia Andreetta, Mauro Mansutti, Gianpiero Fasola |
| المصدر: | Future Oncology. 14:849-859 |
| بيانات النشر: | Future Medicine Ltd, 2018. |
| سنة النشر: | 2018 |
| مصطلحات موضوعية: | Adult, 0301 basic medicine, Oncology, Cancer Research, medicine.medical_specialty, Receptor, ErbB-2, Biopsy, Estrogen receptor, Breast Neoplasms, Disease-Free Survival, 03 medical and health sciences, 0302 clinical medicine, McNemar's test, Internal medicine, Progesterone receptor, Biomarkers, Tumor, medicine, Humans, Aromatase, Aged, Neoplasm Staging, biology, medicine.diagnostic_test, business.industry, General Medicine, Odds ratio, Middle Aged, Prognosis, medicine.disease, Metastatic breast cancer, Primary tumor, Gene Expression Regulation, Neoplastic, Ki-67 Antigen, 030104 developmental biology, Receptors, Estrogen, Lymphatic Metastasis, 030220 oncology & carcinogenesis, biology.protein, Female, Neoplasm Recurrence, Local, Receptors, Progesterone, business |
| الوصف: | Aim: Discordance between primary tumor and paired metastases biology has been widely detected in metastatic breast cancer. The aim of this study was to evaluate the prognostic impact of Ki67, estrogen receptor (ER), progesterone receptor (PR) and HER2 discordance. Methods: We retrospectively analyzed a cohort of 544 patients affected by metastatic breast cancer. Variation in ER, PR, Ki67 and HER2 expression between primary site and recurrence was tested through the McNemar test. Results: A significant variation was observed in respect to ER, PR and Ki67 status (12.65%, p = 0.0072; 49.71%, p |
| تدمد: | 1744-8301 1479-6694 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fab8b600163e4226d5ccc3f952738632Test https://doi.org/10.2217/fon-2017-0384Test |
| حقوق: | CLOSED |
| رقم الانضمام: | edsair.doi.dedup.....fab8b600163e4226d5ccc3f952738632 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 17448301 14796694 |
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