Epigenome-wide association study of maternal hemoglobin A1c in pregnancy and cord blood DNA methylation
| العنوان: | Epigenome-wide association study of maternal hemoglobin A1c in pregnancy and cord blood DNA methylation |
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| المؤلفون: | Andres Cardenas, Anne P. Starling, Patrice Perron, Dana Dabelea, Luigi Bouchard, Diana L Juvinao-Quintero, Marie-France Hivert, Camille E. Powe |
| المصدر: | Epigenomics |
| بيانات النشر: | Future Medicine Ltd, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Adult, 0301 basic medicine, Cancer Research, endocrine system diseases, Offspring, Physiology, 030209 endocrinology & metabolism, Biology, Epigenome, Young Adult, 03 medical and health sciences, 0302 clinical medicine, Pregnancy, Mendelian randomization, Genetics, medicine, Humans, Prospective Studies, Genetic Association Studies, Glycated Hemoglobin, dNaM, DNA Methylation, Glucose Tolerance Test, Fetal Blood, medicine.disease, 3. Good health, Pregnancy Complications, 030104 developmental biology, Hyperglycemia, Pregnancy Trimester, Second, Cord blood, DNA methylation, Gestation, CpG Islands, Female, Cell-Free Nucleic Acids, Research Article |
| الوصف: | Background: Gestational hyperglycemia is associated with adverse perinatal outcomes and long-term offspring metabolic programming, likely through dysregulation of DNA methylation (DNAm). Materials & methods: We tested associations between maternal HbA1c and cord blood DNAm among 412 mother–child pairs in the genetics of glucose regulation in gestation and growth (Gen3G) and implemented Mendelian randomization to infer causality. We sought replication in an independent sample from Healthy Start. Results: Higher second trimester HbA1c levels were associated with lower DNAm at cg21645848 (p = 3.9 × 10-11) near URGCP. Mendelian randomization and replication analyses showed same direction of effect between HbA1c and DNAm at cg21645848, but did not reach statistical significance. Conclusion: We found that higher maternal glycemia reflected by HbA1c is associated with cord blood DNAm at URGCP, a gene related with inflammatory pathways. |
| تدمد: | 1750-192X 1750-1911 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::43adf78954d05dbcdbf81a67bfcfe9b7Test https://doi.org/10.2217/epi-2020-0279Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....43adf78954d05dbcdbf81a67bfcfe9b7 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 1750192X 17501911 |
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