Cytokines and metabolic factors regulate tumoricidal T-cell function during cancer immunotherapy
| العنوان: | Cytokines and metabolic factors regulate tumoricidal T-cell function during cancer immunotherapy |
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| المؤلفون: | Adam J. Adler, Beiyan Zhou, Payal Mittal, Jeffrey S. Wasser, Joseph M. Ryan, Anthony T. Vella |
| المصدر: | Immunotherapy. 9:71-82 |
| بيانات النشر: | Future Medicine Ltd, 2017. |
| سنة النشر: | 2017 |
| مصطلحات موضوعية: | Cytotoxicity, Immunologic, 0301 basic medicine, T cell, medicine.medical_treatment, Immunology, Antineoplastic Agents, Review, Biology, Immunotherapy, Adoptive, Tumor Necrosis Factor Receptor Superfamily, Member 9, 03 medical and health sciences, Immune system, Cancer immunotherapy, Cell Movement, Neoplasms, Tumor Microenvironment, medicine, Animals, Humans, Immunology and Allergy, CD134, Tumor microenvironment, CD137, Immunotherapy, Receptors, OX40, Combined Modality Therapy, CTL, Glucose, 030104 developmental biology, medicine.anatomical_structure, Oncology, Cytokines, Tumor Escape, T-Lymphocytes, Cytotoxic |
| الوصف: | Recent advances in cancer biology and genetics have fostered precision therapies targeting tumor-specific attributes. Immune-based therapies that elicit cytolytic T cells (CTL) specific for tumor antigens can provide therapeutic benefit to cancer patients, however, cure rates are typically low. This largely results from immunosuppressive mechanisms operating within the tumor microenvironment, many of which inflict metabolic stresses upon CTL. Conversely, immunotherapies can mitigate specific metabolic stressors. For instance, dual costimulation immunotherapy with CD134 (OX40) plus CD137 (4–1BB) agonists appears to mediate tumor control in part by engaging cytokine networks that enable infiltrating CTL to compete for limiting supplies of glucose. Future efforts combining modalities that endow CTL with complimentary metabolic advantages should improve therapeutic efficacies. |
| تدمد: | 1750-7448 1750-743X |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bf5829e5d11b371d2cf6d144b8393957Test https://doi.org/10.2217/imt-2016-0097Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....bf5829e5d11b371d2cf6d144b8393957 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 17507448 1750743X |
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