Reduced-intensity or myeloablative allogeneic hematopoietic cell transplantation for mantle cell lymphoma: a systematic review
| العنوان: | Reduced-intensity or myeloablative allogeneic hematopoietic cell transplantation for mantle cell lymphoma: a systematic review |
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| المؤلفون: | Taiga Nishihori, Mohamed A. Kharfan-Dabaja, Tea Reljic, Ambuj Kumar, Mehdi Hamadani, Jessica El-Asmar, Ernesto Ayala |
| المصدر: | Future Oncology. 12:2631-2642 |
| بيانات النشر: | Future Medicine Ltd, 2016. |
| سنة النشر: | 2016 |
| مصطلحات موضوعية: | Oncology, Cancer Research, medicine.medical_specialty, Transplantation Conditioning, medicine.medical_treatment, Lymphoma, Mantle-Cell, Hematopoietic stem cell transplantation, Disease-Free Survival, 03 medical and health sciences, 0302 clinical medicine, hemic and lymphatic diseases, Internal medicine, medicine, Humans, Transplantation, Homologous, Hematopoietic cell, business.industry, Hematopoietic Stem Cell Transplantation, Reduced intensity, General Medicine, medicine.disease, Transplantation, Regimen, Systematic review, 030220 oncology & carcinogenesis, Immunology, Mantle cell lymphoma, Neoplasm Recurrence, Local, business, 030215 immunology |
| الوصف: | Allogeneic hematopoietic cell transplantation (allo-HCT) is the only known treatment that can offer a cure in mantle cell lymphoma, but it is unclear if regimen dose-intensity offers any advantage. We performed a systematic review/meta-analysis to assess efficacy of allo-HCT using myeloablative or reduced-intensity conditioning. We report results according to the Preferred Reporting Items for Systematic Reviews and Meta-analyses guidelines. On the basis of a relatively lower nonrelapse mortality and a slightly better progression-free survival/event-free survival and overall survival rates, reduced-intensity allo-HCT regimens appear to be the preferred choice when an allo-HCT is being considered for mantle cell lymphoma. The higher rate of relapse when offering reduced-intensity regimens cannot be ignored but certainly highlights opportunities to incorporate post-transplant strategies to mitigate this risk. A prospective comparative study is ultimately needed to generate more conclusive evidence. |
| تدمد: | 1744-8301 1479-6694 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a1009a098817b3f885a976bcaf6d3860Test https://doi.org/10.2217/fon-2016-0146Test |
| رقم الانضمام: | edsair.doi.dedup.....a1009a098817b3f885a976bcaf6d3860 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 17448301 14796694 |
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