Association of ERCC1 SNPs with outcome in platinum-treated patients with advanced urothelial cancer: a Hellenic Cooperative Oncology Group study
| العنوان: | Association of ERCC1 SNPs with outcome in platinum-treated patients with advanced urothelial cancer: a Hellenic Cooperative Oncology Group study |
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| المؤلفون: | Nikitas, N., Karadimou, A., Tsitoura, E., Soupos, N., Tsiatas, M., Karavasilis, V., Pectasides, Dimitrios, Pavlidis, Nicholas, Chrisofos, M., Adamakis, I., Murray, S., Fountzilas, George, Dimopoulos, M. A., Bamias, A. T. |
| المساهمون: | Pavlidis, Nicholas [0000-0002-2195-9961], Karavasilis, V. [0000-0002-5806-9399] |
| المصدر: | Pharmacogenomics |
| بيانات النشر: | Future Medicine Ltd, 2012. |
| سنة النشر: | 2012 |
| مصطلحات موضوعية: | Male, Oncology, Genetic association studies, Messenger rna, medicine.medical_treatment, Kaplan-Meier Estimate, Biomarkers, Pharmacological, Carboplatin, chemistry.chemical_compound, Cancer specific survival, Genotype, Urothelial cancer, Treatment outcome, Single nucleotide, Middle aged, Survival time, Single-nucleotide polymorphism, Platinum derivative, Genetic analysis, Homozygote, Urogenital tract cancer, Human ercc1 gene, Middle Aged, Excision repair cross complementing protein 1, Polymerase chain reaction, Urologic neoplasms, DNA-Binding Proteins, Treatment Outcome, Molecular Medicine, Female, Cancer chemotherapy, Restriction fragment length polymorphism, Human, medicine.drug, Adult, Heterozygote, Urologic Neoplasms, medicine.medical_specialty, Disease-free survival, Drug response, Major clinical study, Biology, Vinblastine, Polymorphism, Single Nucleotide, Article, Disease-Free Survival, Dose densification, Advanced cancer, Internal medicine, Genetics, medicine, Humans, Polymorphism, Genotyping, Genetic Association Studies, Aged, Neoplasm Staging, Platinum, Gene amplification, Pharmacology, Cisplatin, Cancer prognosis, Chemotherapy, Pharmacological, Dna, Kaplan-meier estimate, Endonucleases, Gemcitabine, Gene frequency, Dna-binding proteins, Single nucleotide polymorphism, Nucleotide excision repair, Methotrexate, chemistry, Doxorubicin, Ercc1 gene, Pharmacogenetics, Neoplasm staging, Genetic association, Cancer patient, Progression free survival, ERCC1, Biomarkers |
| الوصف: | Aim: The association between two polymorphisms of ERCC1 and treatment outcomes after platinum-based chemotherapy in patients with advanced urothelial cancer (UC) was examined. Materials & methods: Genotyping of 19007C>T and 8092C>A polymorphisms was determined by PCR amplification and RFLP in 113 advanced UC patients, treated with platinum-based chemotherapy. Results: Seventy eight patients (69%) were carriers of the 19007T polymorphic allele: 51 (45%) heterozygotes and 27 (24%) homozygotes. Fifty three (47%) patients were carriers of the 8092A polymorphic allele: the frequencies of C/A and A/A genotypes were 37% and 10%, respectively. The T/T genotype was independently associated with prolonged median cancer-specific survival (not-reached vs 14.8 months; p = 0.026). There was no interaction between T/T or any other genotype with the type of platinum derivative (cisplatin/carboplatin). Conclusion: 19007C>T, especially in its homozygotic state, but not 8092C>A polymorphism, could be a useful prognostic marker in advanced UC treated with platinum-based chemotherapy. Original submitted 17 July 2012; Revision submitted 21 September 2012 |
| تدمد: | 1744-8042 1462-2416 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1bfc0cb1987b72088a3d20615db03225Test https://doi.org/10.2217/pgs.12.162Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....1bfc0cb1987b72088a3d20615db03225 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 17448042 14622416 |
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