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Exploiting Necroptosis for Therapy of Acute Lymphoblastic Leukemia

التفاصيل البيبلوغرافية
العنوان: Exploiting Necroptosis for Therapy of Acute Lymphoblastic Leukemia
المؤلفون: Mezzatesta, Caterina, Bornhauser, Beat C
المصدر: Mezzatesta, Caterina; Bornhauser, Beat C (2019). Exploiting Necroptosis for Therapy of Acute Lymphoblastic Leukemia. Frontiers in Cell and Developmental Biology, 7:40.
بيانات النشر: Frontiers Research Foundation
سنة النشر: 2019
المجموعة: University of Zurich (UZH): ZORA (Zurich Open Repository and Archive
مصطلحات موضوعية: Medical Clinic, 610 Medicine & health
الوصف: Escape from chemotherapy-induced apoptosis is a hallmark of drug resistance in cancer. The recent identification of alternative programmed cell death pathways opens up for possibilities to circumvent the apoptotic blockade in drug resistant cancer and eliminate malignant cells. Indeed, we have recently shown that programmed necrosis, termed necroptosis, could be triggered to induce cell death in a subgroup of primary acute lymphoblastic leukemia (ALL) including highly refractory relapsed cases. In this review we focus on molecular mechanisms that drive drug resistance in ALL of childhood and discuss the potential of necroptosis activation to eradicate resistant disease.
نوع الوثيقة: article in journal/newspaper
وصف الملف: application/pdf
اللغة: English
تدمد: 2296-634X
العلاقة: https://www.zora.uzh.ch/id/eprint/178767/1/fcell-07-00040.pdfTest; info:pmid/30941349; urn:issn:2296-634X
DOI: 10.5167/uzh-178767
DOI: 10.3389/fcell.2019.00040
الإتاحة: https://doi.org/10.5167/uzh-17876710.3389/fcell.2019.00040Test
https://www.zora.uzh.ch/id/eprint/178767Test/
https://www.zora.uzh.ch/id/eprint/178767/1/fcell-07-00040.pdfTest
حقوق: info:eu-repo/semantics/openAccess ; Creative Commons: Attribution 4.0 International (CC BY 4.0) ; http://creativecommons.org/licenses/by/4.0Test/
رقم الانضمام: edsbas.403C644B
قاعدة البيانات: BASE
الوصف
تدمد:2296634X
DOI:10.5167/uzh-178767