التفاصيل البيبلوغرافية
| العنوان: |
Amphetamine Promotes Cortical Up State in Part Via Dopamine Receptors |
| المؤلفون: |
Shen, Guofang, Shi, Wei-Xing |
| المصدر: |
Frontiers in Pharmacology ; volume 12 ; ISSN 1663-9812 |
| بيانات النشر: |
Frontiers Media SA |
| سنة النشر: |
2021 |
| المجموعة: |
Frontiers (Publisher - via CrossRef) |
| مصطلحات موضوعية: |
Pharmacology (medical), Pharmacology |
| الوصف: |
Cortical neurons oscillate between Up and Down states during slow wave sleep and general anesthesia. Recent studies show that Up/Down oscillations also occur during quiet wakefulness. Arousal eliminates Down states and transforms Up/Down oscillations to a persistent Up state. Further evidence suggests that Up/Down oscillations are crucial to memory consolidation, whereas their transition to a persistent Up state is essential for arousal and attention. We have shown that D -amphetamine promotes cortical Up state, and the effect depends on activation of central α 1A adrenergic receptors. Here, we report that dopamine also plays a role in D -amphetamine’s effect. Thus, using local-field-potential recording in the prefrontal cortex in chloral hydrate-anesthetized rats, we showed that the Up-state promoting effect of D -amphetamine was attenuated by antagonists at either D1 or D2-like dopamine receptors. The effect was also partially mimicked by co-activation of D1 and D2-like receptors. These results are consistent with the fact that D -amphetamine increases the release of both norepinephrine and dopamine. They are also in agreement with studies showing that dopamine promotes wakefulness and mediates D -amphetamine-induced emergence from general anesthesia. The effect of D -amphetamine was not mimicked, however, by activation of either D1 or D2-like receptors alone, indicating an interdependence between D1 and D2-like receptors. The dopamine/norepinephrine precursor L-DOPA also failed to promote the Up state. While more studies are needed to understand the difference between L-DOPA and D -amphetamine, our finding may provide an explanation for why L-DOPA lacks significant psychostimulant properties and is ineffective in treating attention-deficit/hyperactivity disorder. |
| نوع الوثيقة: |
article in journal/newspaper |
| اللغة: |
unknown |
| DOI: |
10.3389/fphar.2021.728729 |
| DOI: |
10.3389/fphar.2021.728729/full |
| الإتاحة: |
https://doi.org/10.3389/fphar.2021.728729Test |
| حقوق: |
https://creativecommons.org/licenses/by/4.0Test/ |
| رقم الانضمام: |
edsbas.A94E5B89 |
| قاعدة البيانات: |
BASE |
