المؤلفون: Marie Sofie Møller, Daisy Jonkers, Antoine H. P. America, Colette Larré, Peter R. Shewry, Birte Svensson, Xin Huang, Daniel Keszthelyi, Luud J.W.J. Gilissen, Stefano D'Amico, Fred Brouns, Heinrich Grausgruber, Giacomo Caio, Sabrina Geisslitz, Stefania Masci, Victor F. Zevallos, Roberto De Giorgio, Peter Louis Weegels, Matthew Daly, Mark E. Sorrells, Clare Mills

المساهمون: Department of Food and Nutrition, Grain Technology, Karlsruher Institut für Technologie (KIT), Rothamsted Research, Fac Hlth Med & Life Sci, Dept Human Biol, Nutr & Toxicol Res Inst Maastricht NUTRIM, Maastricht University [Maastricht], Wageningen University and Research [Wageningen] (WUR), Università degli Studi di Ferrara (UniFE), IHU-LIRYC, Université Bordeaux Segalen - Bordeaux 2-CHU Bordeaux [Bordeaux], Austrian Agency for Health and Food Safety (AGES), Department of internal medicine and gastroenterology, Alma Mater Studiorum Università di Bologna [Bologna] (UNIBO)-centro unificato di ricerca biomedica apllicata-St Orsola Hospital, University of Vienna [Vienna], University of Helsinki, Unité de recherche sur les Biopolymères, Interactions Assemblages (BIA), Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Università degli studi della Tuscia [Viterbo], University of Manchester [Manchester], Technical University of Denmark [Lyngby] (DTU), Cornell University [New York], University of Northumbria at Newcastle [United Kingdom], Nutrition Committee of the Rank Prize Funds, StichtingWetenschappelijk Onderzoek Limburg (SWOL), UK Research & Innovation (UKRI), Biotechnology and Biological Sciences Research Council (BBSRC) : BB/P016855/1.

المصدر: Frontiers in Nutrition, 8, 667370
Frontiers in nutrition
Frontiers in nutrition, Frontiers media, 2021, 8, pp.667370. ⟨10.3389/fnut.2021.667370⟩
Frontiers in Nutrition, Vol 8 (2021)
Frontiers in Nutrition, 8
Geisslitz, S, Shewry, P, Brouns, F, America, A H P, Caio, G P I, Daly, M, D'Amico, S, De Giorgio, R, Gilissen, L, Grausgruber, H, Huang, X, Jonkers, D, Keszthelyi, D, Larré, C, Masci, S, Mills, C, Møller, M S, Sorrells, M E, Svensson, B, Zevallos, V F & Weegels, P L 2021, ' Wheat ATIs: Characteristics and Role in Human Disease ', Frontiers in Nutrition, vol. 8, 667370 . https://doi.org/10.3389/fnut.2021.667370Test
Frontiers in Nutrition
Frontiers in Nutrition 8 (2021)

مصطلحات موضوعية: 0106 biological sciences, 0301 basic medicine, ALPHA-AMYLASE INHIBITORS, Endocrinology, Diabetes and Metabolism, Review, B400, 01 natural sciences, Human disease, Intestinal inflammation, wheat, [SDV.IDA]Life Sciences [q-bio]/Food engineering, Pathology, TX341-641, genetics, [SDV.IMM.ALL]Life Sciences [q-bio]/Immunology/Allergology, food technology, 2. Zero hunger, education.field_of_study, Wheat grain, Nutrition and Dietetics, Food Chemistry, trypsin-inhibitors, CELIAC-DISEASE, food and beverages, health, IN-VITRO DIGESTION, amylase/trypsin-inhibitors, pathology, Health, Wheat, BIOS Applied Metabolic Systems, PROTEOMIC ANALYSIS, 3143 Nutrition, Life sciences, biology, amylase, INTESTINAL INFLAMMATION, Population, Gluten sensitivity, Biology, LACTIC-ACID BACTERIA, Food technology, NO, 03 medical and health sciences, SDG 3 - Good Health and Well-being, ddc:570, Levensmiddelenchemie, Genetics, education, SALT-SOLUBLE PROTEINS, DIMERIC INHIBITOR, Nutrition, Innate immune system, business.industry, Nutrition. Foods and food supply, Research needs, In vitro digestion, POWDERY MILDEW, Biotechnology, Plant Breeding, 030104 developmental biology, Amylase/trypsin-inhibitors, business, [SDV.AEN]Life Sciences [q-bio]/Food and Nutrition, GLUTEN SENSITIVITY, 010606 plant biology & botany, Food Science

الوصف: Amylase/trypsin-inhibitors (ATIs) comprise about 2–4% of the total wheat grain proteins and may contribute to natural defense against pests and pathogens. However, they are currently among the most widely studied wheat components because of their proposed role in adverse reactions to wheat consumption in humans. ATIs have long been known to contribute to IgE-mediated allergy (notably Bakers' asthma), but interest has increased since 2012 when they were shown to be able to trigger the innate immune system, with attention focused on their role in coeliac disease which affects about 1% of the population and, more recently, in non-coeliac wheat sensitivity which may affect up to 10% of the population. This has led to studies of their structure, inhibitory properties, genetics, control of expression, behavior during processing, effects on human adverse reactions to wheat and, most recently, strategies to modify their expression in the plant using gene editing. We therefore present an integrated account of this range of research, identifying inconsistencies, and gaps in our knowledge and identifying future research needs.Note This paper is the outcome of an invited international ATI expert meeting held in Amsterdam, February 3-5 2020

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::527133defafe8b02e76acbeece12af6bTest
https://publikationen.bibliothek.kit.edu/1000134280Test

المؤلفون: István Molnár, Vijay K. Tiwari, Marianna Rakszegi, Peter R. Shewry, Éva Darkó

المصدر: Frontiers Research Topics ISBN: 9782889639793

مصطلحات موضوعية: business.industry, media_common.quotation_subject, Aegilops, Quality (business), Biology, business, biology.organism_classification, Biotechnology, media_common

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::6506094d1e92edc698c270cb59bf5574Test
https://doi.org/10.3389/978-2-88963-979-3Test

المؤلفون: István Molnár, Vijay K. Tiwari, Marianna Rakszegi, Éva Darkó, Peter R. Shewry

المصدر: Frontiers in Plant Science
Frontiers in Plant Science, Vol 11 (2020)

مصطلحات موضوعية: stress tolerance, business.industry, media_common.quotation_subject, Quality traits, Stress tolerance, Alien introgression, Plant Science, Genome analysis, lcsh:Plant culture, Biology, biology.organism_classification, quality traits, Biotechnology, Editorial, alien introgression, Aegilops, lcsh:SB1-1110, Quality (business), Aegilops sp, business, genome analysis, media_common

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0cb3fbd252cec3add37697ddffbdadb9Test

المؤلفون: Peter R. Shewry, Alison Lovegrove, István Molnár, Lang Laszlo, Zoltán Bedő, Éva Darkó, Marianna Rakszegi, András Farkas, Márta Molnár-Láng, Jaroslav Doležel

المصدر: Frontiers in Plant Science, Vol 8 (2017)

مصطلحات موضوعية: 0106 biological sciences, 0301 basic medicine, Aegilops, Wheat flour, Introgression, β-glucan, Plant Science, lcsh:Plant culture, 01 natural sciences, 03 medical and health sciences, chemistry.chemical_compound, Glutenin, wheat, Botany, Arabinoxylan, lcsh:SB1-1110, Allele, Aegilops geniculata, biology, Chromosome, food and beverages, biology.organism_classification, dietary fiber, arabinoxylan, 030104 developmental biology, chemistry, U and M genomes, biology.protein, 010606 plant biology & botany

الوصف: Cereal grain fiber is an important health-promoting component in the human diet. One option to improve dietary fiber content and composition in wheat is to introduce genes from its wild relatives Aegilops biuncialis and Aegilops geniculata. This study showed that the addition of chromosomes 2Ug, 4Ug, 5Ug, 7Ug, 2Mg, 5Mg, and 7Mg of Ae. geniculata and 3Ub, 2Mb, 3Mb, and 7Mb of Ae. biuncialis into bread wheat increased the seed protein content. Chromosomes 1Ug and 1Mg increased the proportion of polymeric glutenin proteins, while the addition of chromosomes 1Ub and 6Ub led to its decrease. Both Aegilops species had higher proportions of β-glucan compared to arabinoxylan (AX) than wheat lines, and elevated β-glucan content was also observed in wheat chromosome addition lines 5U, 7U, and 7M. The AX content in wheat was increased by the addition of chromosomes 5Ug, 7Ug, and 1Ub while water-soluble AX was increased by the addition of chromosomes 5U, 5M, and 7M, and to a lesser extent by chromosomes 3, 4, 6Ug, and 2Mb. Chromosomes 5Ug and 7Mb also affected the structure of wheat AX, as shown by the pattern of oligosaccharides released by digestion with endoxylanase. These results will help to map genomic regions responsible for edible fiber content in Aegilops and will contribute to the efficient transfer of wild alleles in introgression breeding programs to obtain wheat varieties with improved health benefits. Key Message: Addition of Aegilops U- and M-genome chromosomes 5 and 7 improves seed protein and fiber content and composition in wheat.

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::61ba180f4ef8cad07cbbb3bf18987b3bTest
https://repository.rothamsted.ac.uk/download/068aa7b9c61d729da3916ef132bb974b0ebdebfa21d22b950a424dd4486ab186/7737092/fpls-08-01529.pdfTest