MHC Class I Cross-Presentation by Dendritic Cells Counteracts Viral Immune Evasion
| العنوان: | MHC Class I Cross-Presentation by Dendritic Cells Counteracts Viral Immune Evasion |
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| المؤلفون: | Peggy Marconi, Ulrich H. Koszinowski, Kenneth M. Murphy, Caroline Bernhard, Christine Ried, Thomas Brocker, Alejandro A Castello, Katrin Nopora |
| المصدر: | Frontiers in Immunology, Vol 3 (2012) Frontiers in Immunology |
| بيانات النشر: | Frontiers Media SA, 2012. |
| سنة النشر: | 2012 |
| مصطلحات موضوعية: | lcsh:Immunologic diseases. Allergy, Antigen Presentation, biology, Virus infection, viruses, T cell, Immunology, Antigen presentation, Cross-presentation, Priming (immunology), chemical and pharmacologic phenomena, Virology, Virus, Immune system, medicine.anatomical_structure, MHC class I, biology.protein, medicine, Immunology and Allergy, dendritic cells, cross-priming, lcsh:RC581-607, CD8, Original Research, immune evasion |
| الوصف: | DCs very potently activate CD8(+) T cells specific for viral peptides bound to MHC class I molecules. However, many viruses have evolved immune evasion mechanisms, which inactivate infected DCs and might reduce priming of T cells. Then MHC class I cross-presentation of exogenous viral Ag by non-infected DCs may become crucial to assure CD8(+) T cell responses. Although many vital functions of infected DCs are inhibited in vitro by many different viruses, the contributions of cross-presentation to T cell immunity when confronted with viral immune inactivation in vivo has not been demonstrated up to now, and remains controversial. Here we show that priming of Herpes Simplex Virus (HSV)-, but not murine cytomegalovirus (mCMV)-specific CD8(+) T cells was severely reduced in mice with a DC-specific cross-presentation deficiency. In contrast, while CD8(+) T cell responses to mutant HSV, which lacks crucial inhibitory genes, also depended on CD8α(+) DCs, they were independent of cross-presentation. Therefore HSV-specific CTL-responses entirely depend on the CD8α(+) DC subset, which present via direct or cross-presentation mechanisms depending on the immune evasion equipment of virus. Our data establish the contribution of cross-presentation to counteract viral immune evasion mechanisms in some, but not all viruses. |
| تدمد: | 1664-3224 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c5aaed12a361bb236dbf023fe383dd6Test https://doi.org/10.3389/fimmu.2012.00348Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....0c5aaed12a361bb236dbf023fe383dd6 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 16643224 |
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