Pain Following the Use of Anesthesia Formulation Among Individuals Undergoing Cataract Surgery: A Randomized Controlled Trial
| العنوان: | Pain Following the Use of Anesthesia Formulation Among Individuals Undergoing Cataract Surgery: A Randomized Controlled Trial |
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| المؤلفون: | Mario D. Toro, Dominika Nowakowska, Agnieszka Brzozowska, Michele Reibaldi, Teresio Avitabile, Claudio Bucolo, Paolo Murabito, Clara Chisari, Katarzyna Nowomiejska, Robert Rejdak |
| المساهمون: | Toro, Md, Nowakowska, D, Brzozowska, A, Reibaldi, M, Avitabile, T, Bucolo, C, Murabito, P, Chisari, C, Nowomiejska, K, Rejdak, R. |
| المصدر: | Frontiers in Pharmacology Frontiers in Pharmacology, Vol 11 (2020) |
| بيانات النشر: | Frontiers Media SA, 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | 0301 basic medicine, Lidocaine, Visual analogue scale, medicine.medical_treatment, cataract surgery, intraocular anesthesia, lidocaine, ophthalmologic anesthesia, pain, phenylephrine, tropicamide, law.invention, 03 medical and health sciences, 0302 clinical medicine, Randomized controlled trial, law, Medicine, Pharmacology (medical), In patient, Original Research, Pharmacology, business.industry, Tropicamide, lcsh:RM1-950, Cataract surgery, lcsh:Therapeutics. Pharmacology, 030104 developmental biology, Mood, 030220 oncology & carcinogenesis, Anesthesia, Anesthetic, business, medicine.drug |
| الوصف: | Purpose: To assess the pain intensity of two intracameral anesthetic solutions in patients undergoing cataract surgery and evaluate the factors influencing the patients’ postoperative activities. Methods: Sixty-two patients undergoing cataract surgery were randomized to receive the study drug – a manufactured solution of 0.02% tropicamide/0.31% phenylephrine/1% lidocaine (Mydrane) or a traditional anesthetic formulation - solution of 1% lidocaine/0.025% adrenaline as an intraocular anesthetic. The pain intensity was assessed by Visual Analog Scale for Pain (VAS Pain) and Brief Pain Inventory-short form (BPI) on the next day after the surgery. Results: The mean pain score measured preoperatively with VAS Pain was 0.34 in Mydrane group and 0.09 in the reference group (p = 0.51). There were no statistically significant differences between the two anesthetic methods with respect to pain intensity during the surgery (p = 0.94) and the influence of pain during the last 24 h on activity (p = 0.79), mood (p = 0.31), social contacts (p = 0.29), sleep (p = 0.5) and the joy of life (p = 0.39). Additionally, there was no statistically significant influence of age, sex, lateralization, co-existing ophthalmological diseases (p = 0.98) and post-operative complications (p = 0.4) on the experienced pain measured during the surgery and in the last 24 h. Conclusions: New commercially available intraocular anesthetic solution (Mydrane™) seems to be as effective as off-label traditional anesthetic formulation, in reducing the pain experienced during cataract surgery under topical anesthesia. |
| تدمد: | 1663-9812 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c4d6221232ffe5e3bb6fce92a4bdf75cTest https://doi.org/10.3389/fphar.2020.00440Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....c4d6221232ffe5e3bb6fce92a4bdf75c |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 16639812 |
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