Weft, Warp, and Weave: The Intricate Tapestry of Calcium Channels Regulating T Lymphocyte Function
| العنوان: | Weft, Warp, and Weave: The Intricate Tapestry of Calcium Channels Regulating T Lymphocyte Function |
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| المؤلفون: | Wilfred A. Jefferies, Kyla D. Omilusik, Shawna R. Stanwood, Nohara Lilian |
| المصدر: | Frontiers in Immunology Frontiers in Immunology, Vol 4 (2013) |
| بيانات النشر: | Frontiers Media SA, 2013. |
| سنة النشر: | 2013 |
| مصطلحات موضوعية: | lcsh:Immunologic diseases. Allergy, calcium, Voltage-dependent calcium channel, ORAI1, Chemistry, L-type calcium channels, T cell, Immunology, T-cell receptor, STIM1, Review Article, T lymphocyte, Cell biology, medicine.anatomical_structure, calcium channels, medicine, Immunology and Allergy, Plasma membrane Ca2+ ATPase, T cell signaling, lcsh:RC581-607, Ion channel |
| الوصف: | Calcium (Ca(2+)) is a universal second messenger important for T lymphocyte homeostasis, activation, proliferation, differentiation, and apoptosis. The events surrounding Ca(2+) mobilization in lymphocytes are tightly regulated and involve the coordination of diverse ion channels, membrane receptors, and signaling molecules. A mechanism termed store-operated Ca(2+) entry (SOCE), causes depletion of endoplasmic reticulum (ER) Ca(2+) stores following T cell receptor (TCR) engagement and triggers a sustained influx of extracellular Ca(2+) through Ca(2+) release-activated Ca(2+) (CRAC) channels in the plasma membrane. The ER Ca(2+) sensing molecule, stromal interaction molecule 1 (STIM1), and a pore-forming plasma membrane protein, ORAI1, have been identified as important mediators of SOCE. Here, we review the role of several additional families of Ca(2+) channels expressed on the plasma membrane of T cells that likely contribute to Ca(2+) influx following TCR engagement, particularly highlighting an important role for voltage-dependent Ca(2+) channels (CaV) in T lymphocyte biology. |
| تدمد: | 1664-3224 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1684f627e9ce474d5f36fbc75f6fb606Test https://doi.org/10.3389/fimmu.2013.00164Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....1684f627e9ce474d5f36fbc75f6fb606 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 16643224 |
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