التفاصيل البيبلوغرافية
| العنوان: |
Mouse Models of Antigen Presentation in Hematopoietic Stem Cell Transplantation |
| المؤلفون: |
Koyama, Motoko, Hill, Geoffrey R. |
| المساهمون: |
National Heart, Lung, and Blood Institute |
| المصدر: |
Frontiers in Immunology ; volume 12 ; ISSN 1664-3224 |
| بيانات النشر: |
Frontiers Media SA |
| سنة النشر: |
2021 |
| المجموعة: |
Frontiers (Publisher - via CrossRef) |
| مصطلحات موضوعية: |
Immunology, Immunology and Allergy |
| الوصف: |
Allogeneic stem cell transplantation (alloSCT) is a curative therapy for hematopoietic malignancies. The therapeutic effect relies on donor T cells and NK cells to recognize and eliminate malignant cells, known as the graft-versus-leukemia (GVL) effect. However, off target immune pathology, known as graft-versus-host disease (GVHD) remains a major complication of alloSCT that limits the broad application of this therapy. The presentation of recipient-origin alloantigen to donor T cells is the primary process initiating GVHD and GVL. Therefore, the understanding of spatial and temporal characteristics of alloantigen presentation is pivotal to attempts to separate beneficial GVL effects from detrimental GVHD. In this review, we discuss mouse models and the tools therein, that permit the quantification of alloantigen presentation after alloSCT. |
| نوع الوثيقة: |
article in journal/newspaper |
| اللغة: |
unknown |
| DOI: |
10.3389/fimmu.2021.715893 |
| DOI: |
10.3389/fimmu.2021.715893/full |
| الإتاحة: |
https://doi.org/10.3389/fimmu.2021.715893Test |
| حقوق: |
https://creativecommons.org/licenses/by/4.0Test/ |
| رقم الانضمام: |
edsbas.4BA497D2 |
| قاعدة البيانات: |
BASE |
