Amyloid-beta, Tau, and Cognition in Cognitively Normal Older Individuals: Examining the Necessity to Adjust for Biomarker Status in Normative Data
| العنوان: | Amyloid-beta, Tau, and Cognition in Cognitively Normal Older Individuals: Examining the Necessity to Adjust for Biomarker Status in Normative Data |
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| المؤلفون: | Isabelle Bos, Stephanie J. B. Vos, Willemijn J. Jansen, Rik Vandenberghe, Silvy Gabel, Ainara Estanga, Mirian Ecay-Torres, Jori Tomassen, Anouk den Braber, Alberto Lleó, Isabel Sala, Anders Wallin, Petronella Kettunen, José L. Molinuevo, Lorena Rami, Gaël Chetelat, Vincent de la Sayette, Magda Tsolaki, Yvonne Freund-Levi, Peter Johannsen, The Alzheimer's Disease Neuroimaging Initiative, Gerald P. Novak, Inez Ramakers, Frans R. Verhey, Pieter Jelle Visser |
| المساهمون: | School for Mental Health and Neuroscience - Alzheimer Center Limburg (MUMC), Maastricht University [Maastricht], University Hospitals Leuven [Leuven], Catholic University of Leuven - Katholieke Universiteit Leuven (KU Leuven), Alzheimer Research Centre KU Leuven, Center for Research and Advanced Therapies CITA-Alzheimer Foundation [San Sebastián], VU University Medical Center [Amsterdam], Vrije Universiteit Amsterdam [Amsterdam] (VU), Hospital de la Santa Creu i Sant Pau, Sahlgrenska Academy at University of Gothenburg [Göteborg], Nuffield Department of Clinical Neurosciences [Oxford], University of Oxford, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Universitat Pompeu Fabra [Barcelona] (UPF), Physiopathologie et imagerie des troubles neurologiques (PhIND), Université de Caen Normandie (UNICAEN), Normandie Université (NU)-Normandie Université (NU)-Institut National de la Santé et de la Recherche Médicale (INSERM), Neuropsychologie et imagerie de la mémoire humaine (NIMH), Normandie Université (NU)-Normandie Université (NU)-École pratique des hautes études (EPHE), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Institut National de la Santé et de la Recherche Médicale (INSERM), Service de Neurologie [CHU Caen], Normandie Université (NU)-Normandie Université (NU)-CHU Caen, Normandie Université (NU)-Tumorothèque de Caen Basse-Normandie (TCBN)-Tumorothèque de Caen Basse-Normandie (TCBN), University General Hospital of Thessaloniki AHEPA, Karolinska Institutet [Stockholm], Karolinska University Hospital [Stockholm], Rigshospitalet [Copenhagen], Copenhagen University Hospital, University of Copenhagen = Københavns Universitet (UCPH), Janssen Pharmaceutical Research and Development Titusville, CHETELAT, Gaëlle, Vrije universiteit = Free university of Amsterdam [Amsterdam] (VU), University of Oxford [Oxford], Normandie Université (NU)-Normandie Université (NU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-École pratique des hautes études (EPHE), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL), University of Copenhagen = Københavns Universitet (KU), RS: MHeNs - R1 - Cognitive Neuropsychiatry and Clinical Neuroscience, Psychiatrie & Neuropsychologie, Promovendi MHN, MUMC+: MA Med Staf Spec Psychiatrie (9), Neurology, Amsterdam Neuroscience - Neurodegeneration, VU University Amsterdam |
| المصدر: | Frontiers in Aging Neuroscience r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau instname Frontiers in Aging Neuroscience, 2018, 10, pp.193. ⟨10.3389/fnagi.2018.00193⟩ Frontiers in Aging Neuroscience, Frontiers, 2018, 10, pp.193. ⟨10.3389/fnagi.2018.00193⟩ Frontiers in Aging Neuroscience, 10:193. Frontiers Media S.A. Frontiers in Aging Neuroscience, Vol 10 (2018) The Alzheimer's Disease Neuroimaging Initiative 2018, ' Amyloid-β, Tau, and Cognition in Cognitively Normal Older Individuals : Examining the Necessity to Adjust for Biomarker Status in Normative Data ', Frontiers in Aging Neuroscience, vol. 10, 193 . https://doi.org/10.3389/fnagi.2018.00193Test |
| بيانات النشر: | FRONTIERS MEDIA SA, 2018. |
| سنة النشر: | 2018 |
| مصطلحات موضوعية: | PRECLINICAL ALZHEIMERS-DISEASE, 0301 basic medicine, cognition, Aging, Geriatrics & Gerontology, neuropsychological examination, Trail Making Test, 0302 clinical medicine, PARTICIPANTS, Verbal fluency test, tau, Original Research, INTERNATIONAL WORKSHOP, DEMENTIA, Neuropsychology, Cognition, CEREBROSPINAL-FLUID BIOMARKERS, IMPAIRMENT, Alzheimer's disease, normative data, humanities, amyloid-beta, PREVALENCE, Cognitive test, Neurology, [SDV.NEU]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC], Psychology, Life Sciences & Biomedicine, Clinical psychology, DIAGNOSTIC-CRITERIA, Cognitive Neuroscience, education, DIAGNOSIS, Verbal learning, lcsh:RC321-571, 03 medical and health sciences, AGE, INFLAMMATION, medicine, Dementia, [SDV.NEU] Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC], lcsh:Neurosciences. Biological psychiatry. Neuropsychiatry, DECLINE, Science & Technology, Neurosciences, ADULTS, medicine.disease, 030104 developmental biology, Normative, Neurosciences & Neurology, 030217 neurology & neurosurgery |
| الوصف: | We investigated whether amyloid-β (Aβ) and tau affected cognition in cognitively normal (CN) individuals, and whether norms for neuropsychological tests based on biomarker-negative individuals would improve early detection of dementia. We included 907 CN individuals from 8 European cohorts and from the Alzheimer's disease Neuroimaging Initiative. All individuals were aged above 40, had Aβ status and neuropsychological data available. Linear mixed models were used to assess the associations of Aβ and tau with five neuropsychological tests assessing memory (immediate and delayed recall of Auditory Verbal Learning Test, AVLT), verbal fluency (Verbal Fluency Test, VFT), attention and executive functioning (Trail Making Test, TMT, part A and B). All test except the VFT were associated with Aβ status and this influence was augmented by age. We found no influence of tau on any of the cognitive tests. For the AVLT Immediate and Delayed recall and the TMT part A and B, we calculated norms in individuals without Aβ pathology (Aβ- norms), which we validated in an independent memory-clinic cohort by comparing their predictive accuracy to published norms. For memory tests, the Aβ- norms rightfully identified an additional group of individuals at risk of dementia. For non-memory test we found no difference. We confirmed the relationship between Aβ and cognition in cognitively normal individuals. The Aβ- norms for memory tests in combination with published norms improve prognostic accuracy of dementia. ispartof: FRONTIERS IN AGING NEUROSCIENCE vol:10 ispartof: location:Switzerland status: published |
| وصف الملف: | application/pdf; Electronic-eCollection |
| تدمد: | 1663-4365 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::448513254e72beb38c40c84d5ce830a5Test https://iibsantpau.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=14047Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....448513254e72beb38c40c84d5ce830a5 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 16634365 |
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