Case report: Cytokine hemoadsorption in a case of hemophagocytic lymphohistiocytosis secondary to extranodal NK/T-cell lymphoma
| العنوان: | Case report: Cytokine hemoadsorption in a case of hemophagocytic lymphohistiocytosis secondary to extranodal NK/T-cell lymphoma |
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| المؤلفون: | Juan Carlos Ruiz-Rodríguez, Luis Chiscano-Camón, Adolf Ruiz-Sanmartin, Clara Palmada, Ivan Bajaña, Gloria Iacoboni, Camilo Bonilla, Alejandra García-Roche, Erika Paola Plata-Menchaca, Carolina Maldonado, Marcos Pérez-Carrasco, Mónica Martinez-Gallo, Clara Franco-Jarava, Manuel Hernández-González, Ricard Ferrer |
| المساهمون: | Institut Català de la Salut, [Ruiz-Rodríguez JC, Chiscano-Camón L, Ruiz-Sanmartin A, Plata-Menchaca E, Pérez-Carrasco M, Ferrer R] Servei de Medicina Intensiva, Vall d'Hebron Hospital Universitari, Barcelona, Spain. Grup de Recerca de Shock, Disfunció Orgànica i Ressuscitació, Vall d'Hebron Institut de Recerca (VHIR), Barcelona, Spain. Vall d'Hebron Hospital Universitari, Barcelona, Spain. Departament de Medicina, Universitat Autònoma de Barcelona, Bellaterra, Spain. [Palmada C, Bajaña I, Bonilla C, García-Roche A, Maldonado C] Servei de Medicina Intensiva, Vall d'Hebron Hospital Universitari, Barcelona, Spain. Grup de Recerca de Shock, Disfunció Orgànica i Ressuscitació, Vall d'Hebron Institut de Recerca (VHIR), Barcelona, Spain. Vall d'Hebron Hospital Universitari, Barcelona, Spain. [Iacoboni G] Departament de Medicina, Universitat Autònoma de Barcelona, Bellaterra, Spain. Servei d’Hematologia, Vall d'Hebron Hospital Universitari, Barcelona, Spain. Experimental Hematology, Vall d'Hebron Institute of Oncology (VHIO), Barcelona, Spain. [Martinez-Gallo M] Departament de Medicina, Universitat Autònoma de Barcelona, Bellaterra, Spain. Servei d’Immunologia, Vall d'Hebron Hospital Universitari, Barcelona, Spain. Grup de Recerca d’Immunologia Translacional, Vall d'Hebron Institut de Recerca (VHIR), Barcelona, Spain. Departament de Biologia Cel·lular, Fisiologia i Immunologia, Universitat Autònoma de Barcelona, Bellaterra, Spain. [Franco-Jarava C] Servei d’Immunologia, Vall d'Hebron Hospital Universitari, Barcelona, Spain. Grup de Recerca d’Immunologia Translacional, Vall d'Hebron Institut de Recerca (VHIR), Barcelona, Spain. [Hernández-González M] Servei d’Immunologia, Vall d'Hebron Hospital Universitari, Barcelona, Spain. Grup de Recerca d’Immunologia Translacional, Vall d'Hebron Institut de Recerca (VHIR), Barcelona, Spain. Departament de Biologia Cel·lular, Fisiologia i Immunologia, Universitat Autònoma de Barcelona, Bellaterra, Spain, Vall d'Hebron Barcelona Hospital Campus |
| المصدر: | Scientia |
| بيانات النشر: | Frontiers Media SA, 2022. |
| سنة النشر: | 2022 |
| مصطلحات موضوعية: | Therapeutics::Sorption Detoxification::Hemoperfusion [ANALYTICAL, DIAGNOSTIC AND THERAPEUTIC TECHNIQUES, AND EQUIPMENT], Macròfags, Citocines, enfermedades hematológicas y linfáticas::enfermedades linfáticas::hisitiocitosis::histiocitosis de células no Langerhans::linfohistiocitosis hemofagocítica [ENFERMEDADES], Other subheadings::/therapy [Other subheadings], terapéutica::desintoxicación por adsorción::hemoperfusión [TÉCNICAS Y EQUIPOS ANALÍTICOS, DIAGNÓSTICOS Y TERAPÉUTICOS], General Medicine, Cèl·lules - Proliferació, Otros calificadores::/terapia [Otros calificadores], Hemic and Lymphatic Diseases::Lymphatic Diseases::Histiocytosis::Histiocytosis, Non-Langerhans-Cell::Lymphohistiocytosis, Hemophagocytic [DISEASES] |
| الوصف: | Cytokine hemoadsorption; Hemophagocytic lymphohistiocytosis; Multiorgan dysfunction Hemoadsorció de citocines; Limfohistiocitosi hemofagocítica; Disfunció multiorgànica Hemoadsorción de citoquinas; Linfohistiocitosis hemofagocítica; Disfunción multiorgánica We discuss a single case of Hemophagocytic lymphohistiocytosis (HLH) due to NK-type non-Hodgkin lymphoma and Epstein-Barr virus reactivation with multiorgan dysfunction and distributive shock in which we performed cytokine hemoadsorption with Cytosorb ®. A full microbiological panel was carried out, including screening for imported disease, standard serologies and cultures for bacterial and fungal infection. A liver biopsy and bone marrow aspirate were performed, confirming the diagnosis. The patients fulfilled the HLH-2004 diagnostic criteria, and according to the 2018 Consensus Statements by the HLH Steering Committee of the Histiocyte Society, dexamethasone and etoposide were started. There was an associated hypercytokinemia and, due to refractory distributive shock, rescue therapy with cytokine hemoadsorption was performed during 24 h (within day 2 and 3 from ICU admission). After starting this procedure, rapid hemodynamic control was achieved with a significant reduction in vasopressor support requirements. This case report highlights that cytokine hemoadsorption can be an effective since rapid decrease in IL-10 levels and a significant hemodynamic improvement was achieved. |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 2296-858X |
| DOI: | 10.3389/fmed.2022.925751 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c763949ab20eef509c1a53f06809e6eTest |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....1c763949ab20eef509c1a53f06809e6e |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 2296858X |
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| DOI: | 10.3389/fmed.2022.925751 |