Characterization of Definitive Regulatory B Cell Subsets by Cell Surface Phenotype, Function and Context
| العنوان: | Characterization of Definitive Regulatory B Cell Subsets by Cell Surface Phenotype, Function and Context |
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| المؤلفون: | Savannah D. Neu, Bonnie N. Dittel |
| المصدر: | Frontiers in Immunology, Vol 12 (2021) Frontiers in Immunology |
| بيانات النشر: | Frontiers Media SA, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | B-Lymphocytes, Regulatory, Encephalomyelitis, Autoimmune, Experimental, Multiple Sclerosis, BDL, autoimmunity, Immunology, B-Lymphocyte Subsets, Review, RC581-607, regulatory B cell (Breg cell), Immunophenotyping, Treg, EAE (experimental autoimmune encephalomyelitis), IL-10, Animals, Humans, Immunology and Allergy, multiple scleorsis (MS), Immunologic diseases. Allergy |
| الوصف: | Regulatory B cell or “Breg” is a broad term that represents the anti-inflammatory activity of B cells, but does not describe their individual phenotypes, specific mechanisms of regulation or relevant disease contexts. Thus, given the variety of B cell regulatory mechanisms reported in human disease and their animal models, a more thorough and comprehensive identification strategy is needed for tracking and comparing B cell subsets between research groups and in clinical settings. This review summarizes the discovery process and mechanism of action for well-defined regulatory B cell subsets with an emphasis on the mouse model of multiple sclerosis experimental autoimmune encephalomyelitis. We discuss the importance of conducting thorough B cell phenotyping along with mechanistic studies prior to defining a particular subset of B cells as Breg. Since virtually all B cell subsets can exert regulatory activity, it is timely for their definitive identification across studies. |
| تدمد: | 1664-3224 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e268ade254a022f3a522009de4c2e200Test https://doi.org/10.3389/fimmu.2021.787464Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....e268ade254a022f3a522009de4c2e200 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 16643224 |
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