Low Virologic Failure and Drug Resistance among HIV-Infected Patients Receiving Hospital-Based ART While Care and Outreach through Community in Guangxi, China
| العنوان: | Low Virologic Failure and Drug Resistance among HIV-Infected Patients Receiving Hospital-Based ART While Care and Outreach through Community in Guangxi, China |
|---|---|
| المؤلفون: | Zhiyong Shen, Wei Kan, Xuebing Leng, Fuxiong Liang, Zhenzhu Tang, Shujia Liang, Yiming Shao, Wei Liu, Hui Xing, Jing Yan, Lingjie Liao, Yuhua Ruan |
| المصدر: | Frontiers in Public Health Frontiers in Public Health, Vol 3 (2015) |
| بيانات النشر: | Frontiers Media SA, 2015. |
| سنة النشر: | 2015 |
| مصطلحات موضوعية: | antiretroviral treatment, Drug injection, China, medicine.medical_specialty, drug resistance, Traditional medicine, virologic suppression, business.industry, Transmission (medicine), lcsh:Public aspects of medicine, Public Health, Environmental and Occupational Health, HIV, lcsh:RA1-1270, Drug resistance, Logistic regression, Outreach, VIROLOGIC FAILURE, Regimen, Internal medicine, medicine, Public Health, business, Viral load, Original Research |
| الوصف: | Objectives To investigate human immunodeficiency virus (HIV) virologic suppression and drug resistance among HIV-infected patients receiving first-line antiretroviral treatment (ART) in hospitals while community care and outreach through local health workers in Guangxi, China. Design This was a series of cross-sectional surveys from 2004 to 2012 in Guangxi, supported by the Chinese National HIVDR Surveillance and Monitoring Network Working Group. Settings Guangxi, China. Methods Demographic, ART, and laboratory data (CD4+ cell count, viral load, and drug resistance) were analyzed. Factors associated with virologic suppression were identified by logistic regression analysis. Results A total of 780 patients were included in this study. The median treatment duration was 20.6 months (IQR 6.6–35.9). Of 780 study participants, 95.4% of patients (744/780) had HIV virologic suppression. Among these, of the 143 patients who were infected through drug injection, only 10 (7.0%) experienced virologic failure, and the overall prevalence of HIV drug resistance was 2.8% (22/789). Factors associated with virologic suppression in the final multivariate models included self-reported missing doses in the past month (compared to not missing doses in the past month, AOR = 0.2, 95% CI: 0.1–0.6) and initial ART regimen without 3TC (compared to initial ART regimen with 3TC, AOR = 0.2, 95% CI: 0.1–0.4). Moreover, the trend chi-square test showed that the proportion of virologic suppression increased over time from 2004 to 2012 (P = 0.002). Conclusion This study first demonstrated that HIV patients infected through various transmission routes can achieve an excellent treatment outcome in hospitals at or above the county level for free first-line ART in Guangxi. It is an important of ART education and adherence to intervention for achieving better treatment outcomes. |
| تدمد: | 2296-2565 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f07a54d28218bed2adbf9af41ff679d7Test https://doi.org/10.3389/fpubh.2015.00244Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....f07a54d28218bed2adbf9af41ff679d7 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 22962565 |
|---|