Wheat ATIs: Characteristics and Role in Human Disease
| العنوان: | Wheat ATIs: Characteristics and Role in Human Disease |
|---|---|
| المؤلفون: | Marie Sofie Møller, Daisy Jonkers, Antoine H. P. America, Colette Larré, Peter R. Shewry, Birte Svensson, Xin Huang, Daniel Keszthelyi, Luud J.W.J. Gilissen, Stefano D'Amico, Fred Brouns, Heinrich Grausgruber, Giacomo Caio, Sabrina Geisslitz, Stefania Masci, Victor F. Zevallos, Roberto De Giorgio, Peter Louis Weegels, Matthew Daly, Mark E. Sorrells, Clare Mills |
| المساهمون: | Department of Food and Nutrition, Grain Technology, Karlsruher Institut für Technologie (KIT), Rothamsted Research, Fac Hlth Med & Life Sci, Dept Human Biol, Nutr & Toxicol Res Inst Maastricht NUTRIM, Maastricht University [Maastricht], Wageningen University and Research [Wageningen] (WUR), Università degli Studi di Ferrara (UniFE), IHU-LIRYC, Université Bordeaux Segalen - Bordeaux 2-CHU Bordeaux [Bordeaux], Austrian Agency for Health and Food Safety (AGES), Department of internal medicine and gastroenterology, Alma Mater Studiorum Università di Bologna [Bologna] (UNIBO)-centro unificato di ricerca biomedica apllicata-St Orsola Hospital, University of Vienna [Vienna], University of Helsinki, Unité de recherche sur les Biopolymères, Interactions Assemblages (BIA), Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Università degli studi della Tuscia [Viterbo], University of Manchester [Manchester], Technical University of Denmark [Lyngby] (DTU), Cornell University [New York], University of Northumbria at Newcastle [United Kingdom], Nutrition Committee of the Rank Prize Funds, StichtingWetenschappelijk Onderzoek Limburg (SWOL), UK Research & Innovation (UKRI), Biotechnology and Biological Sciences Research Council (BBSRC) : BB/P016855/1. |
| المصدر: | Frontiers in Nutrition, 8, 667370 Frontiers in nutrition Frontiers in nutrition, Frontiers media, 2021, 8, pp.667370. ⟨10.3389/fnut.2021.667370⟩ Frontiers in Nutrition, Vol 8 (2021) Frontiers in Nutrition, 8 Geisslitz, S, Shewry, P, Brouns, F, America, A H P, Caio, G P I, Daly, M, D'Amico, S, De Giorgio, R, Gilissen, L, Grausgruber, H, Huang, X, Jonkers, D, Keszthelyi, D, Larré, C, Masci, S, Mills, C, Møller, M S, Sorrells, M E, Svensson, B, Zevallos, V F & Weegels, P L 2021, ' Wheat ATIs: Characteristics and Role in Human Disease ', Frontiers in Nutrition, vol. 8, 667370 . https://doi.org/10.3389/fnut.2021.667370Test Frontiers in Nutrition Frontiers in Nutrition 8 (2021) |
| بيانات النشر: | Frontiers Media SA, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | 0106 biological sciences, 0301 basic medicine, ALPHA-AMYLASE INHIBITORS, Endocrinology, Diabetes and Metabolism, Review, B400, 01 natural sciences, Human disease, Intestinal inflammation, wheat, [SDV.IDA]Life Sciences [q-bio]/Food engineering, Pathology, TX341-641, genetics, [SDV.IMM.ALL]Life Sciences [q-bio]/Immunology/Allergology, food technology, 2. Zero hunger, education.field_of_study, Wheat grain, Nutrition and Dietetics, Food Chemistry, trypsin-inhibitors, CELIAC-DISEASE, food and beverages, health, IN-VITRO DIGESTION, amylase/trypsin-inhibitors, pathology, Health, Wheat, BIOS Applied Metabolic Systems, PROTEOMIC ANALYSIS, 3143 Nutrition, Life sciences, biology, amylase, INTESTINAL INFLAMMATION, Population, Gluten sensitivity, Biology, LACTIC-ACID BACTERIA, Food technology, NO, 03 medical and health sciences, SDG 3 - Good Health and Well-being, ddc:570, Levensmiddelenchemie, Genetics, education, SALT-SOLUBLE PROTEINS, DIMERIC INHIBITOR, Nutrition, Innate immune system, business.industry, Nutrition. Foods and food supply, Research needs, In vitro digestion, POWDERY MILDEW, Biotechnology, Plant Breeding, 030104 developmental biology, Amylase/trypsin-inhibitors, business, [SDV.AEN]Life Sciences [q-bio]/Food and Nutrition, GLUTEN SENSITIVITY, 010606 plant biology & botany, Food Science |
| الوصف: | Amylase/trypsin-inhibitors (ATIs) comprise about 2–4% of the total wheat grain proteins and may contribute to natural defense against pests and pathogens. However, they are currently among the most widely studied wheat components because of their proposed role in adverse reactions to wheat consumption in humans. ATIs have long been known to contribute to IgE-mediated allergy (notably Bakers' asthma), but interest has increased since 2012 when they were shown to be able to trigger the innate immune system, with attention focused on their role in coeliac disease which affects about 1% of the population and, more recently, in non-coeliac wheat sensitivity which may affect up to 10% of the population. This has led to studies of their structure, inhibitory properties, genetics, control of expression, behavior during processing, effects on human adverse reactions to wheat and, most recently, strategies to modify their expression in the plant using gene editing. We therefore present an integrated account of this range of research, identifying inconsistencies, and gaps in our knowledge and identifying future research needs.Note This paper is the outcome of an invited international ATI expert meeting held in Amsterdam, February 3-5 2020 |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 2296-861X |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::527133defafe8b02e76acbeece12af6bTest https://publikationen.bibliothek.kit.edu/1000134280Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....527133defafe8b02e76acbeece12af6b |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 2296861X |
|---|