A Regenerative Approach to Canine Osteoarthritis Using Allogeneic, Adipose-Derived Mesenchymal Stem Cells. Safety Results of a Long-Term Follow-Up
| العنوان: | A Regenerative Approach to Canine Osteoarthritis Using Allogeneic, Adipose-Derived Mesenchymal Stem Cells. Safety Results of a Long-Term Follow-Up |
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| المؤلفون: | Éva Monostori, Éva Kriston-Pál, Valeria Szukacsov, Endre Kiss-Toth, Lajos Haracska, Paul Cooper |
| المصدر: | Frontiers in Veterinary Science Frontiers in Veterinary Science, Vol 7 (2020) |
| بيانات النشر: | Frontiers Media SA, 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | dogs, medicine.medical_specialty, 040301 veterinary sciences, Adipose tissue, long-term follow-up, Osteoarthritis, 0403 veterinary science, Cell therapy, 03 medical and health sciences, Internal medicine, medicine, mesenchymal stem cell, 030304 developmental biology, Cause of death, therapy, 0303 health sciences, lcsh:Veterinary medicine, General Veterinary, business.industry, Mesenchymal stem cell, safety of therapy, Cancer, 04 agricultural and veterinary sciences, Brief Research Report, medicine.disease, Transplantation, osteoarthritis, Lameness, lcsh:SF600-1100, Veterinary Science, business |
| الوصف: | Mesenchymal stem cells (MSC) are emerging as an effective therapeutic tool in treating canine osteoarthritis (OA). In this report, we focused on the questions of whether MSC transplantation has long-term beneficial effects for the improvement in motion and also evaluated the safety of MSC injection. Visceral adipose tissue, a surgical waste obtained during routine ovariectomy served as a source of allogeneic MSCs and used to treat OA. Altogether, fifty-eight dogs were transplanted in the study suffering from OA in the elbow (42 animals), hip (5), knee (8), ankle (2), and hock (1). The effect of MSC transplantation was evaluated by the degree of lameness at a 4-5-years follow-up period based on the owners' subjective observations. The results showed that 83% of the OA patients improved or retained improvement in lameness. Clinical safety of the treatment was assessed by evaluating the coincidence of tumors or other diseases and other adverse reactions (such as local inflammation) after MSC cell therapy. Two incidences of local inflammation for |
| وصف الملف: | application/pdf |
| تدمد: | 2297-1769 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c715c4e3d138cdb3e5be146d07345b3bTest https://doi.org/10.3389/fvets.2020.00510Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....c715c4e3d138cdb3e5be146d07345b3b |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 22971769 |
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