Inflammatory Bowel Diseases and Sarcopenia: The Role of Inflammation and Gut Microbiota in the Development of Muscle Failure
| العنوان: | Inflammatory Bowel Diseases and Sarcopenia: The Role of Inflammation and Gut Microbiota in the Development of Muscle Failure |
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| المؤلفون: | Guido Villani, Fabiana Castiglione, Franco Scaldaferri, Anna Testa, Roberto de Sire, Valentina Petito, Olga Maria Nardone |
| المساهمون: | Nardone, O. M., de Sire, R., Petito, V., Testa, A., Villani, G., Scaldaferri, F., Castiglione, F. |
| المصدر: | Frontiers in Immunology, Vol 12 (2021) Frontiers in Immunology |
| بيانات النشر: | Frontiers Media SA, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | 0301 basic medicine, Sarcopenia, Review, Gut flora, Bioinformatics, Inflammatory bowel disease, Pathogenesis, 0302 clinical medicine, Immunology and Allergy, gut-muscle axi, Intestinal Mucosa, Inflammation Mediator, biology, 030211 gastroenterology & hepatology, Inflammation Mediators, medicine.symptom, probiotic, Human, Signal Transduction, Settore MED/12 - GASTROENTEROLOGIA, IBD, Immunology, Inflammation, malnutrition, digestive system, 03 medical and health sciences, Immune system, Insulin resistance, medicine, Animals, Humans, gut-muscle axis, Muscle, Skeletal, gut microbiota, Bacteria, Animal, business.industry, Inflammatory Bowel Disease, muscle wasting, RC581-607, Inflammatory Bowel Diseases, medicine.disease, biology.organism_classification, digestive system diseases, Dysbiosi, Gastrointestinal Microbiome, Malnutrition, 030104 developmental biology, probiotics, inflammation, Dysbiosis, Immunologic diseases. Allergy, business |
| الوصف: | Sarcopenia represents a major health burden in industrialized country by reducing substantially the quality of life. Indeed, it is characterized by a progressive and generalized loss of muscle mass and function, leading to an increased risk of adverse outcomes and hospitalizations. Several factors are involved in the pathogenesis of sarcopenia, such as aging, inflammation, mitochondrial dysfunction, and insulin resistance. Recently, it has been reported that more than one third of inflammatory bowel disease (IBD) patients suffered from sarcopenia. Notably, the role of gut microbiota (GM) in developing muscle failure in IBD patient is a matter of increasing interest. It has been hypothesized that gut dysbiosis, that typically characterizes IBD, might alter the immune response and host metabolism, promoting a low-grade inflammation status able to up-regulate several molecular pathways related to sarcopenia. Therefore, we aim to describe the basis of IBD-related sarcopenia and provide the rationale for new potential therapeutic targets that may regulate the gut-muscle axis in IBD patients. |
| تدمد: | 1664-3224 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::689645018545b35f8de12dcfe1fff4ebTest https://doi.org/10.3389/fimmu.2021.694217Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....689645018545b35f8de12dcfe1fff4eb |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 16643224 |
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