Dendrogenin A and B two new steroidal alkaloides increasing neural responsiveness in deafened guinea pig
| العنوان: | Dendrogenin A and B two new steroidal alkaloides increasing neural responsiveness in deafened guinea pig |
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| المؤلفون: | Michael R. Paillasse, Marc Poirot, Sandrine Silvente-Poirot, Anette Fransson, Philippe de Medina, Mats Ulfendahl |
| المصدر: | Frontiers in Aging Neuroscience, Vol 7 (2015) Frontiers in Aging Neuroscience |
| بيانات النشر: | Frontiers Media S.A., 2015. |
| سنة النشر: | 2015 |
| مصطلحات موضوعية: | Aging, Cognitive Neuroscience, medicine.medical_treatment, Pharmacology, steroidal alkaloid, lcsh:RC321-571, Guinea pig, Neurotrophic factors, Cochlear implant, otorhinolaryngologic diseases, Medicine, Inner ear, lcsh:Neurosciences. Biological psychiatry. Neuropsychiatry, Spiral ganglion, Original Research, electrically-evoked auditory brainstem response, business.industry, cochlear implant, Neomycin, Perilymph, medicine.anatomical_structure, Brainstem, sense organs, business, spiral ganglion neuron, Neuroscience, auditory nerve, medicine.drug |
| الوصف: | Aim: To investigate the therapeutic potential for treating inner ear damage of two new steroidal alkaloid compounds, Dendrogenin A and Dendrogenin B, previously shown to be potent inductors of cell differentiation. Methods: Guinea pigs, unilaterally deafened by neomycin infusion, received a cochlear implant followed by immediate or a 2-week delayed treatment with Dendrogenin A, Dendrogenin B, and, as comparison artificial perilymph and glial cell-line derived neurotrophic factor. After a 4-week treatment period the animals were sacrificed and the cochleae processed for morphological analysis. Electrically-evoked auditory brainstem responses (eABRs) were measured weekly throughout the experiment. Results: Following immediate or delayed Dendrogenin treatment the electrical responsiveness was significantly maintained, in a similar extent as has been shown using neurotrophic factors. Histological analysis showed that the spiral ganglion neurons density was only slightly higher than the untreated group. Conclusions: Our results suggest that Dendrogenins constitute a new class of drugs with strong potential to improve cochlear implant efficacy and to treat neuropathy/synaptopathy related hearing loss. That electrical responsiveness was maintained despite a significantly reduced neural population suggests that the efficacy of cochlear implants is more related to the functional state of the spiral ganglion neurons than merely their number. |
| اللغة: | English |
| تدمد: | 1663-4365 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::49276aff2dcb6d0edd18ef1ee602bd8fTest http://journal.frontiersin.org/Journal/10.3389/fnagi.2015.00145/fullTest |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....49276aff2dcb6d0edd18ef1ee602bd8f |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 16634365 |
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