المؤلفون: Gang Zheng, Zhihao Yang, Hui Qian, Hua Huang, Zhiwei Gu

المصدر: Frontiers in Oncology, Vol 14 (2024)

مصطلحات موضوعية: primary bone lymphoma of the spine, conditional survival, nomogram, survival estimation, SEER primary bone lymphoma of the spine, SEER, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

الوصف: BackgroundThe current survival prediction methodologies for primary bone lymphoma (PBL) of the spine are deficient. This study represents the inaugural utilization of conditional survival (CS) to assess the outcome of this disease. Moreover, our objective was to devise a CS-based nomogram for predicting overall survival (OS) in real-time for spinal PBL.MethodsPatients with PBL of the spine diagnosed between January 2000 and December 2015 were extracted from the Surveillance, Epidemiology, and End Results (SEER) database. The OS was determined through the Kaplan–Meier method. The CS characteristic of patients with spinal PBL was delineated, with the CS being estimated utilizing the formula: CS(α|β) = OS(α+β)/OS(β). CS(α|β) denotes the probability of additional α-year survivorship, assuming the patient has already survived β years after the time of observation. Three methods including univariate Cox regression, best subset regression (BSR) and the least absolute shrinkage and selection operator (LASSO) regression were used to identify predictors for CS-based nomogram construction.ResultsKaplan-Meier analysis was executed to determine the OS rate for these patients, revealing a survival rate of 68% and subsequently 63% at the 3-year and 5-year mark respectively. We then investigated the CS patterning exhibited by these patients and discovered the survival of PBL in the spine progressively improved with time. Meanwhile, through three different prognostic factor selection methods, we identified the best predicter subset including age, tumor histology, tumor stage, chemotherapy and marital status, for survival prediction model construction. Finally, we successfully established and validated a novel CS-based nomogram model for real-time and dynamic survival estimation. Moreover, we further designed a risk stratification system to facilitate the identification of high-risk patients.ConclusionsThis is the first study to analyze the CS pattern of PBL of the spine. And we have also developed a CS-based nomogram that provide dynamic prognostic data in real-time, thereby aiding in the formulation of personalized treatment strategies in clinical practice.

وصف الملف: electronic resource

العلاقة: https://www.frontiersin.org/articles/10.3389/fonc.2024.1356947/fullTest; https://doaj.org/toc/2234-943XTest

الوصول الحر: https://doaj.org/article/3f069e6fb1ee48369c499fb23cda2630Test

المؤلفون: Yixu Zhu, Xuesong Wu, Wenjun Zhang, Haijun Zhang

المصدر: Frontiers in Surgery, Vol 10 (2023)

مصطلحات موضوعية: limb salvage, prevalence, outcomes, population based study, SEER, primary bone cancer in the extremities, Surgery, RD1-811

الوصف: BackgroundMany attempts have been made to induce limb salvage as an alternative to amputation for primary bone cancer in the extremities, but efforts to establish its benefits over amputation yielded inconsistent results with regard to outcomes and functional recovery. This study aimed to investigate the prevalence and therapeutic efficiency of limb-salvage tumor resection in patients with primary bone cancer in the extremities, and to compare it with extremity amputation.MethodsPatients diagnosed with T1-T2/N0/M0 primary bone cancer in the extremities between 2004 and 2019 were retrospectively identified from the Surveillance, Epidemiology, and End Results program database. Cox regression models were used to test for statistical differences between overall survival (OS) and disease-specific survival (DSS). The cumulative mortality rates (CMRs) for non-cancer comorbidities were also estimated. The evidence level in this study was Level IV.ResultsA total of 2,852 patients with primary bone cancer in the extremities were included in this study, among which 707 died during the study period. Of the patients, 72.6% and 20.4% underwent limb-salvage resection and extremity amputation, respectively. In patients with T1/T2-stage bone tumors in the extremities, limb-salvage resection was associated with significantly better OS and DSS than extremity amputation (OS: adjusted HR, 0.63; 95% confidence interval [CI], 0.55–0.77; p

وصف الملف: electronic resource

العلاقة: https://www.frontiersin.org/articles/10.3389/fsurg.2023.1147372/fullTest; https://doaj.org/toc/2296-875XTest

الوصول الحر: https://doaj.org/article/1caa73674d154a72a7bbe070aae5e0feTest

المؤلفون: Zhiya Wu, Yue Teng, Jianqiu Wu, Honglu Zhang, Weiwei Peng, Cheng Meng, Weiyan Tang, Jifeng Feng

المصدر: Frontiers in Medicine, Vol 9 (2022)

مصطلحات موضوعية: methotrexate, primary bone lymphoma, primary bone diffuse large B-cell lymphoma, refractory, case report, Medicine (General), R5-920

الوصف: Primary bone diffuse large B-cell lymphoma (PB-DLBCL) has been rarely reported because of its low incidence. The optimal treatment plan for patients with relapsed/refractory PB-DLBCL remains controversial. In this study, we present a case of a 57-year-old patient with refractory PB-DLBCL to better understand this disease. The patient developed lumbosacral/low extremity pain. A lumbar magnetic resonance imaging (MRI) revealed skeletal lesions with osteolysis in L4-L5 and S1. With the failure of multi-line chemotherapy, the patient developed paralysis of both lower limbs. 18-Fluorinefluorodeoxyglucose positron emission tomography/computed tomography (18F-FDG PET/CT) and MRI showed new lesions in the femoral head, cervical and thoracic vertebrae. We tried to treat the patient with adjuvant radiotherapy and 10 courses of high-dose methotrexate (HD-MTX)-based monotherapy, after which the patient was able to walk and achieved complete remission (CR). To the best of our knowledge, this is the first attempt to use local radiotherapy combined with an HD-MTX regimen successfully for the treatment of refractory PB-DLBCL.

وصف الملف: electronic resource

العلاقة: https://www.frontiersin.org/articles/10.3389/fmed.2022.989590/fullTest; https://doaj.org/toc/2296-858XTest

الوصول الحر: https://doaj.org/article/a08abce9ee0b4e54883fd720ec435f3dTest

المؤلفون: Pooja Bhakta, Zachary E. Hunzeker, Juan D. Garcia, Ayman Youssef, Bradley J. Grant, Rasha Alfattal, Dylan Weaver, Peeyush Bhargava, Ariel Rischall, Tejo Musunuru, Palawinnage V. Muthukumarana, Jayati Mallick, Kirill A. Lyapichev

المصدر: Frontiers in Oncology, Vol 13 (2023)

مصطلحات موضوعية: primary bone lymphoma, diffuse large B cell lymphoma (DLBCL), femur, diaphyseal fracture, pathological fracture, rituximab, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

الوصف: Primary bone lymphoma (PBL) is a rare extranodal presentation within lymphomas and primary bone malignancies. Pathologic fracture (PF) is a common complication of metastatic bone disease but is, rarely, the presentation of a primary bone tumor. We report a case of an 83-year-old man with a history of untreated prostate cancer, presenting with atraumatic fracture of his left femur after months of intermittent pains and weight loss. Radiographic workup revealed a lytic lesion suspicious for PF secondary to metastatic prostate cancer; however, initial core biopsy results were inconclusive for malignancy. A complete blood count with differential and complete metabolic panel was within normal limits. During surgical fixation and nailing of the femur, a reaming biopsy was performed as a repeat measure and revealed diffuse large B-cell lymphoma. Staging with positron emission tomography and computed tomography found no evidence of lymphatic or visceral involvement and chemotherapy was promptly initiated. This case highlights the diagnostic workup challenges for PF secondary to PBL, especially in the setting of concurrent malignancy. Because of the non-specific presentation of a lytic lesion on imaging associated with atraumatic fracture, we highlight PBL as an important diagnostic consideration.

وصف الملف: electronic resource

العلاقة: https://www.frontiersin.org/articles/10.3389/fonc.2023.1100559/fullTest; https://doaj.org/toc/2234-943XTest

الوصول الحر: https://doaj.org/article/d9d3b26a880e42e59a10c4b420c1f847Test

المؤلفون: Alison Gartland, Michela Pasello, Frédéric Lézot, Francois Lamoureux

المصدر: Frontiers in Endocrinology, Vol 14 (2023)

مصطلحات موضوعية: primary bone tumors, osteosarcoma, Ewing sarcoma, resistance to treatment, bone microenvironment, clinical analysis, Diseases of the endocrine glands. Clinical endocrinology, RC648-665

وصف الملف: electronic resource

العلاقة: https://www.frontiersin.org/articles/10.3389/fendo.2023.1137736/fullTest; https://doaj.org/toc/1664-2392Test

الوصول الحر: https://doaj.org/article/4ce71667c7a44c498e451028af9218afTest

المؤلفون: Yu Wang, Ping Yu, Feifei Liu, Yuqin Wang, Jiaan Zhu

المصدر: Frontiers in Oncology, Vol 12 (2022)

مصطلحات موضوعية: ultrasound, local recurrence, primary bone tumors, metal implants, limb salvage, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

الوصف: BackgroundEarly detection of local recurrence would improve the survival rate of patients with recurrent bone tumors. There is still no consensus on how to follow up after surgery of primary malignant bone tumors. Therefore, the purpose of this study is to evaluate the diagnostic value of ultrasound (US) for local recurrence after limb salvage by comparing it with other imaging modalities.MethodsWe retrospectively reviewed the medical records of patients who were regularly examined by US in our hospital after primary bone tumor surgery from January 2016 to December 2019, some of which underwent x-ray, computed tomography (CT), or 99mTc-MDP bone scan. Recurrence was determined by pathologic confirmation. The cases were considered a true negative for no recurrence if no clinical or pathologic evidence for recurrence was found at least 6 months after the US examination. The Chi-square test or Fisher exact test was used to compare categorical data. p-values < 0.0083 were considered statistically significant.ResultsA total of 288 cases were finally enrolled in our research, including 66 cases with pathologic results. The sensitivity of US was 95.0%, higher than that of x-ray (29.6%) (p = 0.000). The accuracy of US was 96.9%, higher than that of x-ray (85.6%) (p = 0.000).ConclusionAs a nonradiative and cost-effective examination, US may be used as a routine imaging method for postoperative surveillance of primary bone tumors, especially those with metal implants, if more multicenter prospective studies can be done in the future.

وصف الملف: electronic resource

العلاقة: https://www.frontiersin.org/articles/10.3389/fonc.2022.902317/fullTest; https://doaj.org/toc/2234-943XTest

الوصول الحر: https://doaj.org/article/c66163b46a5d413fbff589948860e7fdTest

المؤلفون: Marta Gomarasca, Giovanni Lombardi, Paola Maroni

المصدر: Frontiers in Cell and Developmental Biology, Vol 10 (2022)

مصطلحات موضوعية: post-translational modifications (PMTs), ubiquitin, SUMO, NEDD8, bone metastasis, primary bone tumors, Biology (General), QH301-705.5

الوصف: Post-translational modifications comprise series of enzymatically-driven chemical modifications, virtually involving the entire cell proteome, that affect the fate of a target protein and, in turn, cell activity. Different classes of modifications can be established ranging from phosphorylation, glycosylation, ubiquitination, acetylation, methylation, lipidation and their inverse reactions. Among these, SUMOylation and NEDDylation are ubiquitin-like multi-enzymatic processes that determine the bound of SUMOs and NEDD8 labels, respectively, on defined amino acidic residues of a specific protein and regulate protein function. As fate-determinants of several effectors and mediators, SUMOylation and NEDDylation play relevant roles in many aspects of tumor cell biology. Bone represents a preferential site of metastasis for solid tumors (e.g., breast and prostate cancers) and the primary site of primitive tumors (e.g., osteosarcoma, chondrosarcoma). Deregulation of SUMOylation and NEDDylation affects different aspects of neoplastic transformation and evolution such as epithelial-mesenchymal transition, adaptation to hypoxia, expression and action of tumor suppressors and oncogenic mediators, and drug resistance. Thereby, they represent potential therapeutic targets. This narrative review aims at describing the involvement and regulation of SUMOylation and NEDDylation in tumor biology, with a specific focus on primary and secondary bone tumors, and to summarize and highlight their potentiality in diagnostics and therapeutic strategies.

وصف الملف: electronic resource

العلاقة: https://www.frontiersin.org/articles/10.3389/fcell.2022.889002/fullTest; https://doaj.org/toc/2296-634XTest

الوصول الحر: https://doaj.org/article/080e5fa8c66d455f9669fa6521266d80Test

المؤلفون: Xin Cao, Hui-Jin Chen

المصدر: Frontiers in Oncology, Vol 11 (2021)

مصطلحات موضوعية: primary bone lymphoma, lymphoma, patella, patellectomy, chemotherapy, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

الوصف: Primary bone lymphoma (PBL) is a rare but distinct clinicopathological disease, usually occurring in the pelvis, spine, and ribs. To date, only a few cases have been reported as beginning in the patella. Due to the lack of clinical evidence, the optimal treatment strategy has not been established. Here, we report a case that presented unexplained right knee pain. The case was diagnosed with the non-germinal center, diffuse large B cell lymphoma in the patella by imaging examinations and bone biopsy. Then, the patient received a patellectomy and eight cycles of R-CHOP chemotherapy. After treatment, the patient achieved a favorable prognosis and satisfactory functional recovery.

وصف الملف: electronic resource

العلاقة: https://www.frontiersin.org/articles/10.3389/fonc.2021.786495/fullTest; https://doaj.org/toc/2234-943XTest

الوصول الحر: https://doaj.org/article/06adaf5a064343ac9f37aa105b86a3d5Test

المؤلفون: Suli Yu, Jianqiang Xu

المصدر: Frontiers in Oncology, Vol 11 (2021)

مصطلحات موضوعية: case report, primary bone lymphoma, peripheral T cell lymphoma, imaging feature, treatment strategy, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

الوصف: Primary bone lymphoma (PBL) is a less frequent type of extranodal lymphoma, which is defined as a single skeletal tumor or multiple bone lesions without visceral or lymph node involvement. Most published cases have reported diffused large B cell lymphoma (DLBCL) of PBL, and the prognosis is good after conventional treatment. Primary T-cell lymphoma is extremely rare in the literature. The clinical symptoms, imaging findings, diagnosis, treatment and prognosis of primary T-cell lymphoma of bone are still unclear. The case details a young male patient who was treated for bone tuberculosis and was diagnosed with T-cell lymphoma during an open surgical biopsy. Further imaging evidence showed the lymphoma was localized within the femur. The patient responded poorly to combined chemo- and radiotherapy. He was confirmed with local lung metastases 11 months later and died at the 17th month of onset. I would like to provide PBL entities with some rare information about primary bone peripheral T-cell lymphoma and discuss the best strategy for the treatment of rare PBL subtypes.

وصف الملف: electronic resource

العلاقة: https://www.frontiersin.org/articles/10.3389/fonc.2021.690819/fullTest; https://doaj.org/toc/2234-943XTest

الوصول الحر: https://doaj.org/article/4c532a097ef64c1fae68976ec37e0ea3Test

المؤلفون: Yuzhang Tao, Xiao Huang, Yiwen Tan, Hongwei Wang, Weiqian Jiang, Yu Chen, Chenglong Wang, Jing Luo, Zhi Liu, Kangrong Gao, Wu Yang, Minkang Guo, Boyu Tang, Aiguo Zhou, Mengli Yao, Tingmei Chen, Youde Cao, Chengsi Luo, Jian Zhang

المصدر: Frontiers in Oncology, Vol 11 (2021)

مصطلحات موضوعية: primary bone tumors, deep learning, histopathological classification, convolutional neural network (CNN), diagnosis, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

الوصف: BackgroundHistopathological diagnosis of bone tumors is challenging for pathologists. We aim to classify bone tumors histopathologically in terms of aggressiveness using deep learning (DL) and compare performance with pathologists.MethodsA total of 427 pathological slides of bone tumors were produced and scanned as whole slide imaging (WSI). Tumor area of WSI was annotated by pathologists and cropped into 716,838 image patches of 256 × 256 pixels for training. After six DL models were trained and validated in patch level, performance was evaluated on testing dataset for binary classification (benign vs. non-benign) and ternary classification (benign vs. intermediate vs. malignant) in patch-level and slide-level prediction. The performance of four pathologists with different experiences was compared to the best-performing models. The gradient-weighted class activation mapping was used to visualize patch’s important area.ResultsVGG-16 and Inception V3 performed better than other models in patch-level binary and ternary classification. For slide-level prediction, VGG-16 and Inception V3 had area under curve of 0.962 and 0.971 for binary classification and Cohen’s kappa score (CKS) of 0.731 and 0.802 for ternary classification. The senior pathologist had CKS of 0.685 comparable to both models (p = 0.688 and p = 0.287) while attending and junior pathologists showed lower CKS than the best model (each p < 0.05). Visualization showed that the DL model depended on pathological features to make predictions.ConclusionDL can effectively classify bone tumors histopathologically in terms of aggressiveness with performance similar to senior pathologists. Our results are promising and would help expedite the future application of DL-assisted histopathological diagnosis for bone tumors.

العلاقة: https://www.frontiersin.org/articles/10.3389/fonc.2021.735739/fullTest; https://doaj.org/toc/2234-943XTest; https://doaj.org/article/d7dfa16893d74ce3a6bb99bb9278d6f1Test

الإتاحة: https://doi.org/10.3389/fonc.2021.735739Test
https://doaj.org/article/d7dfa16893d74ce3a6bb99bb9278d6f1Test