المؤلفون: Massimiliano Borselli, Fausto F. Ferrari, Pietro Bianchi, Costanza Rossi, Giovanna Carnovale Scalzo, Domenica Mangialavori, Vincenzo Scorcia, Giuseppe Giannaccare

المصدر: Frontiers in Ophthalmology, Vol 3 (2023)

مصطلحات موضوعية: curcumin, dry eye disease, ocular surface, tear substitutes, tear film, Medicine

الوصف: The aim of this study is to report the clinical outcomes of oral supplementation with curcumin-phospholipid in addition to hyaluronic acid-based tear substitute for the management of dry eye disease (DED). Patients with a diagnosis of DED confirmed by pathological values of both NIKBUT 12 were included. Patients were randomized to receive 2 different treatments: 0.25% hyaluronic acid-based tear substitute 3 time daily (Group 1) or as above plus curcumin-phosphatidylcholine complex tablets once a day (Group 2). Patients were evaluated at baseline (T0) and after 90 days of treatment (T1) by means of Keratograph for the measurement of NIKBUT, TMH, meibomian gland dropout and bulbar redness. Overall, data from 90 eyes of 45 patients were included. Group 1 consisted of 48 eyes of 24 patients, while group 2 included 42 eyes of 21 patients. When comparing median values of both groups at T0, no statistically significant differences were found for all parameters; instead for T1, statistically significant differences were found for redness and OSDI compared to Group 1. In group 1, a statistically significant reduction after the treatment was detected for Nikbut average and OSDI questionnaire; while in group 2, a statistically significant reduction after treatment was recorded for Nikbut average, bulbar redness and OSDI questionnaire. The addition of an oral supplement containing curcumin-phospholipid may help in a greater improvement of bulbar redness and subjective ocular symptoms compared to the treatment with tear substitutes alone for the management of DED.

وصف الملف: electronic resource

العلاقة: https://www.frontiersin.org/articles/10.3389/fopht.2023.1236525/fullTest; https://doaj.org/toc/2674-0826Test

الوصول الحر: https://doaj.org/article/749637ffb1df4c5281ca1fd432559617Test

المؤلفون: Shamaila Zaman, Raya Almazrouei, Amir H. Sam, Aimee N. DiMarco, Jeannie F. Todd, Fausto F. Palazzo, Tricia Tan, Waljit S. Dhillo, Karim Meeran, Florian Wernig

المصدر: Frontiers in Endocrinology, Vol 12 (2021)

مصطلحات موضوعية: adrenalectomy, synacthen stimulation test, adrenal insufficiency, over-night dexamethasone suppression test, autonomous cortisol secretion, Diseases of the endocrine glands. Clinical endocrinology, RC648-665

الوصف: BackgroundCortisol levels in response to stress are highly variable. Baseline and stimulated cortisol levels are commonly used to determine adrenal function following unilateral adrenalectomy. We report the results of synacthen stimulation testing following unilateral adrenalectomy in a tertiary referral center.MethodsData were collected retrospectively for 36 patients who underwent synacthen stimulation testing one day post unilateral adrenalectomy. None of the patients had clinical signs of hypercortisolism preoperatively. No patient received pre- or intraoperative steroids. Patients with overt Cushing’s syndrome were excluded.ResultsThe median age was 58 (31-79) years. Preoperatively, 16 (44%) patients had a diagnosis of pheochromocytoma, 12 (33%) patients had primary aldosteronism and 8 (22%) patients had non-functioning adenomas with indeterminate/atypical imaging characteristics necessitating surgery. Preoperative overnight dexamethasone suppression test results revealed that 6 of 29 patients failed to suppress cortisol to

وصف الملف: electronic resource

العلاقة: https://www.frontiersin.org/articles/10.3389/fendo.2021.654600/fullTest; https://doaj.org/toc/1664-2392Test

الوصول الحر: https://doaj.org/article/0f58c973711e446997f340718b6e521eTest

المؤلفون: Zaman, Shamaila, Almazrouei, Raya, Sam, Amir H., DiMarco, Aimee N., Todd, Jeannie F., Palazzo, Fausto F., Tan, Tricia, Dhillo, Waljit S., Meeran, Karim, Wernig, Florian

المصدر: Frontiers in Endocrinology; 5/11/2021, Vol. 11, pN.PAG-N.PAG, 7p

مصطلحات موضوعية: ADRENALECTOMY, CUSHING'S syndrome, HYPOTHALAMIC-pituitary-adrenal axis, ADRENAL insufficiency, INAPPROPRIATE prescribing (Medicine)

مستخلص: Background: Cortisol levels in response to stress are highly variable. Baseline and stimulated cortisol levels are commonly used to determine adrenal function following unilateral adrenalectomy. We report the results of synacthen stimulation testing following unilateral adrenalectomy in a tertiary referral center. Methods: Data were collected retrospectively for 36 patients who underwent synacthen stimulation testing one day post unilateral adrenalectomy. None of the patients had clinical signs of hypercortisolism preoperatively. No patient received pre- or intraoperative steroids. Patients with overt Cushing's syndrome were excluded. Results: The median age was 58 (31-79) years. Preoperatively, 16 (44%) patients had a diagnosis of pheochromocytoma, 12 (33%) patients had primary aldosteronism and 8 (22%) patients had non-functioning adenomas with indeterminate/atypical imaging characteristics necessitating surgery. Preoperative overnight dexamethasone suppression test results revealed that 6 of 29 patients failed to suppress cortisol to <50 nmol/L. Twenty (56%) patients achieved a stimulated cortisol ≥450 nmol/L at 30 minutes and 28 (78%) at 60 minutes. None of the patients developed clinical adrenal insufficiency necessitating steroid replacement. Conclusions: Synacthen stimulation testing following unilateral adrenalectomy using standard stimulated cortisol cut-off values would wrongly label many patients adrenally insufficient and may lead to inappropriate prescriptions of steroids to patients who do not need them. [ABSTRACT FROM AUTHOR]

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