دورية أكاديمية

Harnessing Clinical Trial and Real-World Data Towards an Understanding of Sex Effects on Drug Pharmacokinetics, Pharmacodynamics and Efficacy

التفاصيل البيبلوغرافية
العنوان: Harnessing Clinical Trial and Real-World Data Towards an Understanding of Sex Effects on Drug Pharmacokinetics, Pharmacodynamics and Efficacy
المؤلفون: Joyce Oi Yan Chan, Marie Moullet, Beth Williamson, Rosalinda H. Arends, Venkatesh Pilla Reddy
المصدر: Frontiers in Pharmacology, Vol 13 (2022)
بيانات النشر: Frontiers Media S.A., 2022.
سنة النشر: 2022
المجموعة: LCC:Therapeutics. Pharmacology
مصطلحات موضوعية: clinical pharmacology, drug metabolism, pk, sex, POPPK, Therapeutics. Pharmacology, RM1-950
الوصف: Increasing clinical data on sex-related differences in drug efficacy and toxicity has highlighted the importance of understanding the impact of sex on drug pharmacokinetics and pharmacodynamics. Intrinsic differences between males and females, such as different CYP enzyme activity, drug transporter expression or levels of sex hormones can all contribute to different responses to medications. However, most studies do not include sex-specific investigations, leading to lack of sex-disaggregated pharmacokinetic and pharmacodynamic data. Based available literature, the potential influence of sex on exposure-response relationship has not been fully explored for many drugs used in clinical practice, though population-based pharmacokinetic/pharmacodynamic modelling is well-placed to explore this effect. The aim of this review is to highlight existing knowledge gaps regarding the effect of sex on clinical outcomes, thereby proposing future research direction for the drugs with significant sex differences. Based on evaluated drugs encompassing all therapeutic areas, 25 drugs demonstrated a clinically meaningful sex differences in drug exposure (characterised by ≥ 50% change in drug exposure) and this altered PK was correlated with differential response.
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 1663-9812
العلاقة: https://www.frontiersin.org/articles/10.3389/fphar.2022.874606/fullTest; https://doaj.org/toc/1663-9812Test
DOI: 10.3389/fphar.2022.874606
الوصول الحر: https://doaj.org/article/b39525017d5e4cbc8e92c51c81bfdd1aTest
رقم الانضمام: edsdoj.b39525017d5e4cbc8e92c51c81bfdd1a
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:16639812
DOI:10.3389/fphar.2022.874606