دورية أكاديمية
Immune Memory in Mild COVID-19 Patients and Unexposed Donors Reveals Persistent T Cell Responses After SARS-CoV-2 Infection
| العنوان: | Immune Memory in Mild COVID-19 Patients and Unexposed Donors Reveals Persistent T Cell Responses After SARS-CoV-2 Infection |
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| المؤلفون: | Asgar Ansari, Rakesh Arya, Shilpa Sachan, Someshwar Nath Jha, Anurag Kalia, Anupam Lall, Alessandro Sette, Alba Grifoni, Daniela Weiskopf, Poonam Coshic, Ashok Sharma, Nimesh Gupta |
| المصدر: | Frontiers in Immunology, Vol 12 (2021) |
| بيانات النشر: | Frontiers Media S.A., 2021. |
| سنة النشر: | 2021 |
| المجموعة: | LCC:Immunologic diseases. Allergy |
| مصطلحات موضوعية: | human coronavirus, pre-existing immunity, CD4+ T cells, B cells, neutralizing antibody, Immunologic diseases. Allergy, RC581-607 |
| الوصف: | Understanding the causes of the diverse outcome of COVID-19 pandemic in different geographical locations is important for the worldwide vaccine implementation and pandemic control responses. We analyzed 42 unexposed healthy donors and 28 mild COVID-19 subjects up to 5 months from the recovery for SARS-CoV-2 specific immunological memory. Using HLA class II predicted peptide megapools, we identified SARS-CoV-2 cross-reactive CD4+ T cells in around 66% of the unexposed individuals. Moreover, we found detectable immune memory in mild COVID-19 patients several months after recovery in the crucial arms of protective adaptive immunity; CD4+ T cells and B cells, with a minimal contribution from CD8+ T cells. Interestingly, the persistent immune memory in COVID-19 patients is predominantly targeted towards the Spike glycoprotein of the SARS-CoV-2. This study provides the evidence of both high magnitude pre-existing and persistent immune memory in Indian population. By providing the knowledge on cellular immune responses to SARS-CoV-2, our work has implication for the development and implementation of vaccines against COVID-19. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1664-3224 45478198 |
| العلاقة: | https://www.frontiersin.org/articles/10.3389/fimmu.2021.636768/fullTest; https://doaj.org/toc/1664-3224Test |
| DOI: | 10.3389/fimmu.2021.636768 |
| الوصول الحر: | https://doaj.org/article/5ea99187bd6e45478198781c5ee978fbTest |
| رقم الانضمام: | edsdoj.5ea99187bd6e45478198781c5ee978fb |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 16643224 45478198 |
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| DOI: | 10.3389/fimmu.2021.636768 |