دورية أكاديمية

Scleritis in rheumatoid arthritis: Before and during biologic era

التفاصيل البيبلوغرافية
العنوان: Scleritis in rheumatoid arthritis: Before and during biologic era
المؤلفون: Daphne P. C. Vergouwen, Pascal H. P. de Jong, Marco W. J. Schreurs, Josianne C. Ten Berge, Aniki Rothova
المصدر: Frontiers in Ophthalmology, Vol 3 (2023)
بيانات النشر: Frontiers Media S.A., 2023.
سنة النشر: 2023
المجموعة: LCC:Medicine
مصطلحات موضوعية: scleritis, rheumatoid arthritis, incidence, prevalence, rheumatoid factor (RF), anti-citrullinated protein antibodies (ACPAs), Medicine
الوصف: ObjectivesScleritis represents a severe extra-articular manifestation of rheumatoid arthritis (RA). Recent clinical observations suggest a decreasing incidence of scleritis in RA, attributed to improved treatment options. Our study reports on the incidence and clinical characteristics of scleritis in RA observed in the biological era and reflects on our results in a historical perspective.MethodsWe performed a retrospective evaluation of all 1623 consecutive patients with RA diagnosed at the department of rheumatology between 2011 and 2021 at the Erasmus Medical Center to investigate the incidence of scleritis. We also reviewed clinical and laboratory data of all patients with scleritis and RA from the department of ophthalmology at our center. In addition, we reviewed the literature on this topic and discuss our results in view of changes over time.ResultsThe incidence of scleritis within recent series of patients with a diagnosis of RA in our tertiary center was 0,25% in 10 years (4 out of 1623; 2011-2021).The cumulative incidence of scleritis in RA based on literature review from the pre-biologic era varied from 0.7% per 8 years to 0,8% per 30 years. Manifestations and complications of scleritis remained unchanged over time, with scleral necrosis developing in more than 80% of cases and mortality of RA patients with scleritis remained similar to pre-biologic era (30% in 9 years after the onset of scleritis). The RA patients with scleritis often exhibited autoantibodies (rheumatoid factor and/or anti-citrullinated protein antibody) and erosive disease.ConclusionAlthough our recent series is characterized by a slightly lower incidence of scleritis in RA compared to the pre-biologic era, clinical presentation remained severe and similar to the pre-biologic era. Ophthalmologists and rheumatologists should be aware of scleritis as a severe extra-articular manifestation of RA.
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 2674-0826
العلاقة: https://www.frontiersin.org/articles/10.3389/fopht.2023.1106419/fullTest; https://doaj.org/toc/2674-0826Test
DOI: 10.3389/fopht.2023.1106419
الوصول الحر: https://doaj.org/article/54d89604e7cb4544b2831cdf7d277081Test
رقم الانضمام: edsdoj.54d89604e7cb4544b2831cdf7d277081
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:26740826
DOI:10.3389/fopht.2023.1106419