التفاصيل البيبلوغرافية
| العنوان: |
Control of Immunoregulatory Molecules by miRNAs in T Cell Activation. |
| المؤلفون: |
Rodríguez-Galán, Ana, Fernández-Messina, Lola, Sánchez-Madrid, Francisco |
| المصدر: |
Frontiers in Immunology; 9/25/2018, pN.PAG-N.PAG, 10p |
| مصطلحات موضوعية: |
T cells, MICRORNA, T cell differentiation, SUPPRESSOR cells, LYMPHOCYTE transformation, PHYSIOLOGY |
| مستخلص: |
MiRNA targeting of key immunoregulatory molecules fine-tunes the immune response. This mechanism boosts or dampens immune functions to preserve homeostasis while supporting the full development of effector functions. MiRNA expression changes during T cell activation, highlighting that their function is constrained by a specific spatiotemporal frame related to the signals that induce T cell-based effector functions. Here, we update the state of the art regarding the miRNAs that are differentially expressed during T cell stimulation. We also revisit the existing data on miRNA function in T cell activation, with a special focus on the modulation of the most relevant immunoregulatory molecules. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
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