التفاصيل البيبلوغرافية
| العنوان: |
Predicting AT(N) pathologies in Alzheimer's disease from blood-based proteomic data using neural networks. |
| المؤلفون: |
Yuting Zhang, Ghose, Upamanyu, Buckley, Noel J., Engelborghs, Sebastiaan, Sleegers, Kristel, Frisoni, Giovanni B., Wallin, Anders, Lleó, Alberto, Popp, Julius, Martinez-Lage, Pablo, Legido-Quigley, Cristina, Barkhof, Frederik, Zetterberg, Henrik, Visser, Pieter Jelle, Bertram, Lars, Lovestone, Simon, Nevado-Holgado, Alejo J., Liu Shi |
| المصدر: |
Frontiers in Aging Neuroscience; 11/30/2022, Vol. 14, p1-10, 10p |
| مصطلحات موضوعية: |
DEEP learning, BIOMARKERS, DISEASE progression, COGNITION disorders, RESEARCH, KRUSKAL-Wallis Test, ALZHEIMER'S disease, BLOOD proteins, PREDICTIVE tests, DNA, NEURAL pathways, ANALYSIS of variance, CONFIDENCE intervals, TAU proteins, BLOOD plasma, MILD cognitive impairment, MACHINE learning, MANN Whitney U Test, AMYLOID beta-protein precursor, PROTEOMICS, CONCEPTUAL structures, GENOTYPES, DESCRIPTIVE statistics, CHI-squared test, RESEARCH funding, ARTIFICIAL neural networks, COMBINED modality therapy, DATA analysis software, RECEIVER operating characteristic curves, LONGITUDINAL method, DIFFUSION of innovations, DISEASE complications |
| مستخلص: |
Background and objective: Blood-based biomarkers represent a promising approach to help identify early Alzheimer's disease (AD). Previous research has applied traditional machine learning (ML) to analyze plasma omics data and search for potential biomarkers, but the most modern ML methods based on deep learning has however been scarcely explored. In the current study, we aim to harness the power of state-of-the-art deep learning neural networks (NNs) to identify plasma proteins that predict amyloid, tau, and neurodegeneration (AT[N]) pathologies in AD. Methods: We measured 3,635 proteins using SOMAscan in 881 participants from the European Medical Information Framework for AD Multimodal Biomarker Discovery study (EMIF-AD MBD). Participants underwent measurements of brain amyloid β (Aβ) burden, phosphorylated tau (p-tau) burden, and total tau (t-tau) burden to determine their AT(N) statuses. We ranked proteins by their association with Aβ, p-tau, t-tau, and AT(N), and fed the top 100 proteins along with age and apolipoprotein E (APOE) status into NN classifiers as input features to predict these four outcomes relevant to AD. We compared NN performance of using proteins, age, and APOE genotype with performance of using age and APOE status alone to identify protein panels that optimally improved the prediction over these main risk factors. Proteins that improved the prediction for each outcome were aggregated and nominated for pathway enrichment and protein-protein interaction enrichment analysis. Results: Age and APOE alone predicted Aβ, p-tau, t-tau, and AT(N) burden with area under the curve (AUC) scores of 0.748, 0.662, 0.710, and 0.795. The addition of proteins significantly improved AUCs to 0.782, 0.674, 0.734, and 0.831, respectively. The identified proteins were enriched in five clusters of AD-associated pathways including human immunodeficiency virus 1 infection, p53 signaling pathway, and phosphoinositide-3-kinase-protein kinase B/Akt signaling pathway. Conclusion: Combined with age and APOE genotype, the proteins identified have the potential to serve as blood-based biomarkers for AD and await validation in future studies. While the NNs did not achieve better scores than the support vector machine model used in our previous study, their performances were likely limited by small sample size. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
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