-
1
المؤلفون: Weijun Zhou, Sipper Khan, Zarmaha Amina, Hafiz Muhammad Usman Aslam, Amina Nisar, Shakra Jamil, Rafaqat A. Gill, Rahil Shahzad, Shakeel Ahmad, Shamsa Kanwal
المصدر: Frontiers in Nutrition
Frontiers in Nutrition, Vol 8 (2021)مصطلحات موضوعية: Endocrinology, Diabetes and Metabolism, Population, Biofortification, Review, malnutrition, Biology, anti-nutrients, Crop, Nutrient, medicine, genome editing, TX341-641, CRISPR-Cas, education, Nutrition, transgenic breeding, education.field_of_study, Nutrition and Dietetics, conventional breeding, Nutrition. Foods and food supply, business.industry, food and beverages, Staple food, medicine.disease, Micronutrient, Biotechnology, Mineral fertilization, Malnutrition, fertilization, micronutrients, business, Food Science
الوصف: Cereals and pulses are consumed as a staple food in low-income countries for the fulfillment of daily dietary requirements and as a source of micronutrients. However, they are failing to offer balanced nutrition due to deficiencies of some essential compounds, macronutrients, and micronutrients, i.e., cereals are deficient in iron, zinc, some essential amino acids, and quality proteins. Meanwhile, the pulses are rich in anti-nutrient compounds that restrict the bioavailability of micronutrients. As a result, the population is suffering from malnutrition and resultantly different diseases, i.e., anemia, beriberi, pellagra, night blindness, rickets, and scurvy are common in the society. These facts highlight the need for the biofortification of cereals and pulses for the provision of balanced diets to masses and reduction of malnutrition. Biofortification of crops may be achieved through conventional approaches or new breeding techniques (NBTs). Conventional approaches for biofortification cover mineral fertilization through foliar or soil application, microbe-mediated enhanced uptake of nutrients, and conventional crossing of plants to obtain the desired combination of genes for balanced nutrient uptake and bioavailability. Whereas, NBTs rely on gene silencing, gene editing, overexpression, and gene transfer from other species for the acquisition of balanced nutritional profiles in mutant plants. Thus, we have highlighted the significance of conventional and NBTs for the biofortification of cereals and pulses. Current and future perspectives and opportunities are also discussed. Further, the regulatory aspects of newly developed biofortified transgenic and/or non-transgenic crop varieties via NBTs are also presented.
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07abc232e913a2e793e43e253640a6efTest
http://europepmc.org/articles/PMC8528959Test -
2
المؤلفون: Shauna M. Downs, Archna Singh, Satabdi Barman, Jessica Fanzo, Ridhima Kapoor, Geetanjali Singh, Suparna Ghosh-Jerath
المصدر: Frontiers in Nutrition, Vol 7 (2021)
Frontiers in Nutritionمصطلحات موضوعية: 0301 basic medicine, Endocrinology, Diabetes and Metabolism, lcsh:TX341-641, underutilized indigenous foods, nutritive value, Indigenous, 03 medical and health sciences, 0302 clinical medicine, Sustainable agriculture, medicine, 030212 general & internal medicine, Traditional knowledge, Socioeconomics, Nutrition, Original Research, Government, 030109 nutrition & dietetics, Nutrition and Dietetics, Food security, business.industry, indigenous foods, medicine.disease, Focus group, Malnutrition, Geography, factors affecting indigenous food consumption, Agriculture, micronutrients, business, traditional food environment, lcsh:Nutrition. Foods and food supply, Munda tribes, Food Science
الوصف: Indigenous food (IF) systems, derived from natural ecosystems are perceived to be sustainable and nutritionally adequate. Mundas, an indigenous tribal community in Jharkhand India, are surrounded by rich agroforestry resources, yet display high levels of malnutrition. Our study explored the food environment of Munda community, different IFs they accessed, levels of utilization of IFs in routine diets, their nutritional attributes and factors influencing IF consumption. A cross-sectional mixed-methods study was conducted in nine villages of Murhu and Torpa blocks in Khunti district, Jharkhand. Using focus group discussions and key informant interviews, we did free-listing of IFs known to the community. This was followed by enumerating preferred and little used/historically consumed IFs, along with reasons. Qualitative enquiries were recorded and transcribed verbatim; data were coded and analyzed using thematic framework approach. The listed IFs were identified through common names and photographs, and verified by ethnobotanist in the team. The nutritive values of identified IFs were searched in literature or nutritional analysis of specific plant based foods were undertaken in an accredited laboratory. The community demonstrated traditional ecological knowledge of several IFs (n= 194), which are accessed from wild, cultivated and built food environments. Taxonomic classification was available for 80% (n= 156) IFs, out of which 60 foods had nutritive values in secondary literature and 42 foods were analyzed in laboratory. Many IFs were rich in micronutrients like calcium, iron, folate, vitamin A and C. Among the listed IFs, only 45% were commonly consumed, while rest were little used/historically consumed. Factors like desirable taste, satiety, perceived nutrition benefits, adaptability to climate variability, traditional practice of food preservation and their cultural importance promoted IF consumption. However, local climatic impacts on agroforestry systems, easy access to foods bought from markets or distributed under government food security schemes, and promotion of hybrid seeds by local agricultural organizations, emerged as potential barriers. Thus, reinforcement of traditional ecological knowledge and informal food literacy, along with promotion of climate resilient attributes of IFs, can contribute to sustainable food systems in Munda community.
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4bec4872f15130d49a11c081ede831afTest
https://www.frontiersin.org/articles/10.3389/fnut.2020.600470/fullTest -
3
المؤلفون: Mukesh K. Pandey, Sunil Q. Mehta, Supriya Behl
المصدر: Frontiers in Molecular Neuroscience
Frontiers in Molecular Neuroscience, Vol 13 (2020)مصطلحات موضوعية: 0301 basic medicine, Physiology, magnesium, lcsh:RC321-571, 03 medical and health sciences, Cellular and Molecular Neuroscience, 0302 clinical medicine, iron, mental disorders, Medicine, Molecular Biology, lcsh:Neurosciences. Biological psychiatry. Neuropsychiatry, business.industry, Gene ontology, zinc, medicine.disease, Serum samples, Micronutrient, biometals, 030104 developmental biology, Autism spectrum disorder, metal micronutrients, copper, Perspective, selenium and autism spectrum disorder, business, 030217 neurology & neurosurgery, Neuroscience
الوصف: The aim of the present review is to summarize the prevalence of abnormal levels of various metal micronutrients including copper (Cu), iron (Fe), magnesium (Mg), zinc (Zn), and selenium (Se) in Autism Spectrum Disorder (ASD) using hair, nail and serum samples. A correlation of selected abnormal metal ions with known neurodevelopmental processes using Gene Ontology (GO) term was also conducted. Data included in this review are derived from ASD clinical studies performed globally. Metal ion disparity data is also analyzed and discussed based on gender (Male/Female) to establish any gender dependent correlation. Finally, a rational perspective and possible path to better understand the role of metal micronutrients in ASD is suggested.
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bc40ecb151e8ce83ec334ea00c0923dfTest
http://europepmc.org/articles/PMC7759187Test -
4
المؤلفون: Emre Sahin, Cemal Orhan, Fatih M. Uckun, Kazim Sahin
المصدر: Frontiers in Nutrition, Vol 7 (2020)
Frontiers in Nutritionمصطلحات موضوعية: 0301 basic medicine, medicine.medical_specialty, Endocrinology, Diabetes and Metabolism, Psychological intervention, 030209 endocrinology & metabolism, lcsh:TX341-641, Disease, Review, 03 medical and health sciences, 0302 clinical medicine, Nutrient, Pandemic, medicine, Global health, Intensive care medicine, 030109 nutrition & dietetics, Nutrition and Dietetics, business.industry, SARS-CoV-2, Micronutrient, medicine.disease, Comorbidity, cytokines, Clinical trial, nutrition, inflammation, micronutrients, business, lcsh:Nutrition. Foods and food supply, Food Science
الوصف: The emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) disease (COVID-19) in China at the end of 2019 caused a major global pandemic and continues to be an unresolved global health crisis. The supportive care interventions for reducing the severity of symptoms along with participation in clinical trials of investigational treatments are the mainstay of COVID-19 management because there is no effective standard therapy for COVID-19. The comorbidity of COVID-19 rises in obese patients. Micronutrients may boost the host immunity against viral infections, including COVID-19. In this review, we discuss the clinical impact potential of supplemental nutrients as adjuncts of therapy in high-risk COVID-19 for obese patients.
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fe6f1f7e8548eade7db7511fc8e2c6f3Test
https://www.frontiersin.org/articles/10.3389/fnut.2020.580504/fullTest -
5
المؤلفون: Ghizlane Bendriss, Dalia Zakaria, Ali Chaari, Clare McVeigh
المصدر: Frontiers in Public Health, Vol 8 (2020)
Frontiers in Public Healthمصطلحات موضوعية: medicine.medical_specialty, Coronavirus disease 2019 (COVID-19), macronutrients, coronavirus, Nutritional Status, Review, medicine.disease_cause, balanced diet, 03 medical and health sciences, 0302 clinical medicine, Immune system, Environmental health, Intermittent fasting, Pandemic, medicine, Humans, 030212 general & internal medicine, Pandemics, Immunodeficiency, Coronavirus, SARS-CoV-2, intermittent fasting, business.industry, 030503 health policy & services, Public health, lcsh:Public aspects of medicine, Immunity, Public Health, Environmental and Occupational Health, COVID-19, lcsh:RA1-1270, medicine.disease, Micronutrient, immune system, probiotics, micronutrients, Public Health, 0305 other medical science, business
الوصف: The new coronavirus pandemic continues to spread causing further public health, social, and economic issues. The disparities in the rates of death between countries poses questions about the importance of lifestyle habits and the immune status of populations. An exploration of dietary habits and COVID-19-related death might unravel associations between these two variables. Indeed, while both nutritional excess and deficiency are associated with immunodeficiency, adequate nutrition leading to an optimally functioning immune system may be associated with better outcomes with regards to preventing infection and complications of COVID-19, as well as developing a better immune response to other pathogenic viruses and microorganisms. This article outlines the key functions of the immune system and how macronutrients, micronutrients, and metabolites from the gut microbiome can be essential in the development of an efficient immune system. In addition, the effects of intermittent fasting on the inflammatory state as well as metabolic parameters will be discussed.
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b59aad97e108014b49af8cc266e77cbTest
https://www.frontiersin.org/article/10.3389/fpubh.2020.00476/fullTest -
6
المؤلفون: Emérita del Carmen Pons, Enrique Murillo, Marilyn E. Scott, Odalis Sinisterra, Kristine G. Koski, Delfina Rueda, Doris González-Fernández
المصدر: Frontiers in Public Health
Frontiers in Public Health, Vol 8 (2020)مصطلحات موضوعية: medicine.medical_specialty, Mean arterial pressure, Ambulatory blood pressure, Anemia, protein status, Pregnancy, High-Risk, Blood Pressure, Gastroenterology, 03 medical and health sciences, 0302 clinical medicine, Pregnancy, Internal medicine, medicine, symphysis-fundal height, Humans, 030212 general & internal medicine, Original Research, Inflammation, business.industry, 030503 health policy & services, lcsh:Public aspects of medicine, uro-genital infections, Public Health, Environmental and Occupational Health, lcsh:RA1-1270, Nutrients, pulse pressure, Blood Pressure Monitoring, Ambulatory, medicine.disease, Micronutrient, Pulse pressure, Blood pressure, Cross-Sectional Studies, micronutrients, Cohort, nematodes, MAP, Female, Public Health, 0305 other medical science, business
الوصف: Background: Ambulatory blood pressure is a potential tool for early detection of complications during pregnancy, but its utility in impoverished settings has not been assessed. This cross-sectional study aimed to determine whether maternal infections, nutrient deficiencies and inflammation (MINDI) were associated with four measures of maternal blood pressure (BP) and to determine their association with symphysis-fundal-height (SFH).Methods: Environmental and dietary factors, intake of iron and a multiple-nutrient supplement (MNS), markers of inflammation, protein, anemia, folate, vitamins B12, A and D status, and urogenital, skin, oral and intestinal nematode infections were measured in indigenous pregnant Panamanian women. Stepwise multiple linear and logistic regression models explored determinants of systolic and diastolic blood pressure (SBP, DBP), hypotension (SBP < 100 and DBP < 60), mean arterial pressure (MAP), elevated MAP (eMAP), and pulse pressure (PP). Associations of BP with intestinal nematodes and with SFH Z scores (≥16 wk) were also explored.Results: Despite absence of high SBP or DBP, 11.2% of women had eMAP. Furthermore, 24.1% had hypotension. Linear regression showed that hookworm infection was associated with higher SBP (P = 0.049), DBP (P = 0.046), and MAP (P = 0.016), whereas Ascaris was associated with lower DBP (P = 0.018) and MAP (P = 0.028). Trichomonas was also associated with lower SBP (P < 0.0001) and MAP (P = 0.009). The presence of Trichuris (OR: 6.7, 95% CI 1.0–44.5) and folic acid deficiency (OR: 6.9, 95% CI 1.4–33.8) were associated with increased odds of eMAP. The odds of low BP was higher in the presence of Ascaris (OR: 3.63 ± 2.28, P = 0.040), but odds were lowered by MNS (OR: 0.35 ± 0.11, P = 0.001), more intake of animal-source foods/wk (OR: 0.7, 95% CI 0.5–0.9) and by higher concentrations of IL-17 (OR: 0.87 ± 0.05, P = 0.016).Conclusion: MINDI were bi-directionally associated with blood pressure indicators. In this MINDI cohort, infections, nutrients and cytokines both raised, and lowered BP indices. The presence of eMAP identified pregnant women at risk of hypertension whereas low PP was associated with lower SFH. Therefore, MAP and PP may help in detecting women at risk of adverse pregnancy outcomes in settings with limited access to technology.
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dfb480682a1df4df2991c1e7b591c7cbTest
http://europepmc.org/articles/PMC7121149Test -
7The Impact of Western Diet and Nutrients on the Microbiota and Immune Response at Mucosal Interfaces
المؤلفون: Donjete Statovci, Mònica Aguilera, John MacSharry, Silvia Melgar
المصدر: Frontiers in Immunology
Frontiers in Immunology, Vol 8 (2017)مصطلحات موضوعية: 0301 basic medicine, lcsh:Immunologic diseases. Allergy, Saturated fat, saturated fat, westernized diet, Immunology, Innate lymphoid cells, Disease, Review, Gut flora, Inflammatory bowel disease, 03 medical and health sciences, Immune system, inflammatory bowel disease, Regulatory t cells, Mesenteric adipose tissue, medicine, microbiota, Westernized diet, Immunology and Allergy, Micronutrients, biology, Microbiota, Sodium induced colitis, Innate lymphoid cell, Crohns disease, asthma, medicine.disease, biology.organism_classification, Obesity, Ulcerative colitis, Asthma, 030104 developmental biology, Vitamin D receptor, micronutrients, Polyunsaturated fatty acids, lcsh:RC581-607, Piama birth cohort
الوصف: Recent findings point toward diet having a major impact on human health. Diets can either affect the gut microbiota resulting in alterations in the host's physiological responses or by directly targeting the host response. The microbial community in the mammalian gut is a complex and dynamic system crucial for the development and maturation of both systemic and mucosal immune responses. Therefore, the complex interaction between available nutrients, the microbiota, and the immune system are central regulators in maintaining homeostasis and fighting against invading pathogens at mucosal sites. Westernized diet, defined as high dietary intake of saturated fats and sucrose and low intake of fiber, represent a growing health risk contributing to the increased occurrence of metabolic diseases, e.g., diabetes and obesity in countries adapting a westernized lifestyle. Inflammatory bowel diseases (IBD) and asthma are chronic mucosal inflammatory conditions of unknown etiology with increasing prevalence worldwide. These conditions have a multifactorial etiology including genetic factors, environmental factors, and dysregulated immune responses. Their increased prevalence cannot solely be attributed to genetic considerations implying that other factors such as diet can be a major contributor. Recent reports indicate that the gut microbiota and modifications thereof, due to a consumption of a diet high in saturated fats and low in fibers, can trigger factors regulating the development and/or progression of both conditions. While asthma is a disease of the airways, increasing evidence indicates a link between the gut and airways in disease development. Herein, we provide a comprehensive review on the impact of westernized diet and associated nutrients on immune cell responses and the microbiota and how these can influence the pathology of IBD and asthma.
وصف الملف: application/pdf
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d169473f8349c4f999e54b2f123866deTest
-
8
المصدر: Frontiers in Neuroscience, Vol 12 (2018)
مصطلحات موضوعية: 0301 basic medicine, Normal diet, Hearing loss, Presbycusis, Physiology, Stimulation, magnesium, lcsh:RC321-571, 03 medical and health sciences, 0302 clinical medicine, Medicine, Young adult, Auditory thresholds, lcsh:Neurosciences. Biological psychiatry. Neuropsychiatry, hearing loss, business.industry, General Neuroscience, aging, medicine.disease, Micronutrient, vitamins, 030104 developmental biology, Auditory brainstem response, micronutrients, medicine.symptom, business, presbycusis, 030217 neurology & neurosurgery
الوصف: The increasing rate of age-related hearing loss (ARHL), with its subsequent reduction in quality of life and increase in health care costs, requires new therapeutic strategies to reduce and delay its impact. The goal of this study was to determine if ARHL could be reduced in a rat model by administering a combination of antioxidant vitamins A, C, and E acting as free radical scavengers along with Mg++, a known powerful cochlear vasodilator (ACEMg). Toward this goal, young adult, 3 month-old Wistar rats were divided into two groups: one was fed with a diet composed of regular chow (“normal diet,” ND); the other received a diet based on chow enriched in ACEMg (“enhanced diet,” ED). The ED feeding began 10 days before the noise stimulation. Auditory brainstem recordings (ABR) were performed at 0.5, 1, 2, 4, 8, 16, and 32 kHz at 3, 6–8, and 12–14 months of age. No differences were observed at 3 months of age, in both ND and ED animals. At 6–8 and 12–14 months of age there were significant increases in auditory thresholds and a reduction in the wave amplitudes at all frequencies tested, compatible with progressive development of ARHL. However, at 6–8 months threshold shifts in ED rats were significantly lower in low and medium frequencies, and wave amplitudes were significantly larger at all frequencies when compared to ND rats. In the oldest animals, differences in the threshold shift persisted, as well as in the amplitude of the wave II, suggesting a protective effect of ACEMg on auditory function during aging. These findings indicate that oral ACEMg may provide an effective adjuvant therapeutic intervention for the treatment of ARHL, delaying the progression of hearing impairment associated with age.
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ac28a3a81f547efec922b9f15fb78a1Test
https://www.frontiersin.org/article/10.3389/fnins.2018.00527/fullTest -
9
المؤلفون: Anett eNyaradi, Jianghong eLi, Siobhan eHickling, Jonathan eFoster, Wendy H Oddy
المصدر: Frontiers in Human Neuroscience, Vol 7 (2013)
Frontiers in Human Neuroscienceمصطلحات موضوعية: Gerontology, Breastfeeding, Review Article, lcsh:RC321-571, Behavioral Neuroscience, children, Cognitive development, medicine, Micronutrients, Children, lcsh:Neurosciences. Biological psychiatry. Neuropsychiatry, Biological Psychiatry, business.industry, Cognition, diet quality, medicine.disease, Micronutrient, Obesity, Psychiatry and Mental health, Malnutrition, Neuropsychology and Physiological Psychology, nutrition, Neurology, micronutrients, ddc:300, Observational study, business, Neurocognitive, Neuroscience, cognitive development
الوصف: This review examines the current evidence for a possible connection between nutritional intake (including micronutrients and whole diet) and neurocognitive development in childhood. Earlier studies which have investigated the association between nutrition and cognitive development have focused on individual micronutrients, including omega-3 fatty acids, vitamin B12, folic acid, choline, iron, iodine, and zinc, and single aspects of diet. The research evidence from observational studies suggests that micronutrients may play an important role in the cognitive development of children. However, the results of intervention trials utilizing single micronutrients are inconclusive. More generally, there is evidence that malnutrition can impair cognitive development, whilst breastfeeding appears to be beneficial for cognition. Eating breakfast is also beneficial for cognition. In contrast, there is currently inconclusive evidence regarding the association between obesity and cognition. Since individuals consume combinations of foods, more recently researchers have become interested in the cognitive impact of diet as a composite measure. Only a few studies to date have investigated the associations between dietary patterns and cognitive development. In future research, more well designed intervention trials are needed, with special consideration given to the interactive effects of nutrients.
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9f321ee85319cf3fd38d8e83c9873b4bTest
http://journal.frontiersin.org/Journal/10.3389/fnhum.2013.00097/fullTest -
10
المؤلفون: Igor Bendik, Manfred Eggersdorfer, Peter Weber, Angelika Friedel, Franz F. Roos
المصدر: Frontiers in Physiology, Vol 5 (2014)
Frontiers in Physiologyمصطلحات موضوعية: Vitamin, hidden hunger, Physiology, vitamin D, Review Article, Nutrigenetics, vitamin D deficiency, lcsh:Physiology, chemistry.chemical_compound, nutrigenomics, Environmental health, Physiology (medical), Vitamin D and neurology, Medicine, lcsh:QP1-981, business.industry, medicine.disease, Micronutrient, 25-hydroxyvitamin D, Biotechnology, Malnutrition, Nutrigenomics, nutrition, chemistry, micronutrients, nutrition security, nutritional pathways, business, Cholecalciferol
الوصف: Vitamin D is a micronutrient that is needed for optimal health throughout the whole life. Vitamin D3 (cholecalciferol) can be either synthesized in the human skin upon exposure to the UV light of the sun, or it is obtained from the diet. If the photoconversion in the skin due to reduced sun exposure (e.g., in wintertime) is insufficient, intake of adequate vitamin D from the diet is essential to health. Severe vitamin D deficiency can lead to a multitude of avoidable illnesses; among them are well-known bone diseases like osteoporosis, a number of autoimmune diseases, many different cancers, and some cardiovascular diseases like hypertension are being discussed. Vitamin D is found naturally in only very few foods. Foods containing vitamin D include some fatty fish, fish liver oils, and eggs from hens that have been fed vitamin D and some fortified foods in countries with respective regulations. Based on geographic location or food availability adequate vitamin D intake might not be sufficient on a global scale. The International Osteoporosis Foundation (IOF) has collected the 25-hydroxy-vitamin D plasma levels in populations of different countries using published data and developed a global vitamin D map. This map illustrates the parts of the world, where vitamin D did not reach adequate 25-hydroxyvitamin D plasma levels: 6.7% of the papers report 25-hydroxyvitamin D plasma levels below 25 nmol/L, which indicates vitamin D deficiency, 37.3% are below 50 nmol/Land only 11.9% found 25-hydroxyvitamin D plasma levels above 75 nmol/L target as suggested by vitamin D experts. The vitamin D map is adding further evidence to the vitamin D insufficiency pandemic debate, which is also an issue in the developed world. Besides malnutrition, a condition where the diet does not match to provide the adequate levels of nutrients including micronutrients for growth and maintenance, we obviously have a situation where enough nutrients were consumed, but lacked to reach sufficient vitamin D micronutrient levels. The latter situation is known as hidden hunger. The inadequate vitamin D status impacts on health care costs, which in turn could result in significant savings, if corrected. Since little is known about the effects on the molecular level that accompany the pandemic like epigenetic imprinting, the insufficiency-triggered gene regulations or the genetic background influence on the body to maintain metabolic resilience, future research will be needed. The nutrition community is highly interested in the molecular mechanism that underlies the vitamin D insufficiency caused effect. In recent years, novel large scale technologies have become available that allow the simultaneous acquisition of transcriptome, epigenome, proteome, or metabolome data in cells of organs. These important methods are now used for nutritional approaches summarized in emerging scientific fields of nutrigenomics, nutrigenetics, or nutriepigenetics. It is believed that with the help of these novel concepts further understanding can be generated to develop future sustainable nutrition solutions to safeguard nutrition security.
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::903263a814aff5d4c4c71ab0d3f2ca2cTest
