A Review on the Role of Small Nucleolar RNA Host Gene 6 Long Non-coding RNAs in the Carcinogenic Processes
| العنوان: | A Review on the Role of Small Nucleolar RNA Host Gene 6 Long Non-coding RNAs in the Carcinogenic Processes |
|---|---|
| المؤلفون: | Soudeh Ghafouri-Fard, Seyedpouzhia Shojaei, Tayyebeh Khoshbakht, Mohammad Taheri |
| المصدر: | Frontiers in Cell and Developmental Biology, Vol 9 (2021) Frontiers in Cell and Developmental Biology |
| بيانات النشر: | Frontiers Media S.A., 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | MAPK/ERK pathway, Cell type, QH301-705.5, Wnt signaling pathway, Review, Cell Biology, Biology, Cell biology, Cell and Developmental Biology, Exon, lncRNA, microRNA, expression, SNHG6, cancer, biomarker, Small nucleolar RNA, Biology (General), Protein kinase B, PI3K/AKT/mTOR pathway, Developmental Biology |
| الوصف: | Being located on 17q25.1, small nucleolar RNA host gene 6 (SNHG16) is a member of SNHG family of long non-coding RNAs (lncRNA) with 4 exons and 13 splice variants. This lncRNA serves as a sponge for a variety of miRNAs, namely miR-520a-3p, miR-4500, miR-146a miR-16–5p, miR-98, let-7a-5p, hsa-miR-93, miR-17-5p, miR-186, miR-302a-3p, miR-605-3p, miR-140-5p, miR-195, let-7b-5p, miR-16, miR-340, miR-1301, miR-205, miR-488, miR-1285-3p, miR-146a-5p, and miR-124-3p. This lncRNA can affect activity of TGF-β1/SMAD5, mTOR, NF-κB, Wnt, RAS/RAF/MEK/ERK and PI3K/AKT pathways. Almost all studies have reported oncogenic effect of SNHG16 in diverse cell types. Here, we explain the results of studies about the oncogenic role of SNHG16 according to three distinct sets of evidence, i.e., in vitro, animal, and clinical evidence. |
| اللغة: | English |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9965cdbded72a3b2147bf2cc2b5f6f68Test https://www.frontiersin.org/articles/10.3389/fcell.2021.741684/fullTest |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....9965cdbded72a3b2147bf2cc2b5f6f68 |
| قاعدة البيانات: | OpenAIRE |
| الوصف غير متاح. |